Results 91 to 100 of about 2,895 (162)

The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing

Nature Communications
Antibiotic heteroresistance, characterized by rare resistant subpopulations of bacteria within a susceptible main population, is associated with treatment failure and often caused by tandem amplification of resistance genes. Here, we investigated how the
Sofia Jonsson, Andrei Guliaev, Brandon A. Berryhill, Dan I. Andersson, Hervé Nicoloff   +4 more
doaj   +1 more source

Fluoroquinolones and rifampin combination in the backdrop of heteroresistant tuberculosis

Antimicrobial Agents and Chemotherapy
ABSTRACT The impact of heteroresistance on tuberculosis (TB) treatment outcomes is unclear, as is the role of different rifampin and isoniazid exposures on developing resistance mutations. Hollow fiber system model of TB (HFS-TB) units were inoculated with drug-susceptible Mycobacterium ...
Vanessa B. Vogensen, Sanjay Singh, Christopher J. Allende, David M. Engelthaler, Gunavanthi D. Boorgula, Tania A. Thomas, Marieke G. G. Sturkenboom, Onno W. Akkerman, Tawanda Gumbo, Shashikant Srivastava   +9 more
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Heteroresistance in Mycobacterium tuberculosis: from molecular mechanisms and advanced detection to clinical implications

Frontiers in Cellular and Infection Microbiology
Drug resistance in Mycobacterium species, particularly Mycobacterium tuberculosis, remains a protracted and severe challenge to global public health.
Shibo Liu, Dan Chen, Juanjue Zhang, Mingli Zhu   +3 more
doaj   +1 more source

Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms

Xiehe Yixue Zazhi
Polymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise.
LI Yanbing, ZHOU Menglan, XU Yingchun
doaj   +1 more source

Genetic Evaluation of Heteroresistance among Carbapenem-Susceptible Clinical Isolates of Enterobacterales

Canadian Journal of Infectious Diseases and Medical Microbiology
Carbapenems currently serve as the last line of defense when treating serious infections caused by multidrug-resistant Enterobacterales species; however, heteroresistance of these species is thought to cause failure in the treatment with these broad ...
İpek Koçer, Mehmet Eri̇nmez, Yasemin Zer   +2 more
doaj   +1 more source

Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance

Nature Communications
Heteroresistance is a medically relevant phenotype where small antibiotic-resistant subpopulations coexist within predominantly susceptible bacterial populations. Heteroresistance reduces treatment efficacy across diverse bacterial species and antibiotic
Hervé Nicoloff, Karin Hjort, Dan I. Andersson, Helen Wang   +3 more
doaj   +1 more source

Heterogeneous subpopulations in Escherichia coli strains acquire adaptive resistance to imipenem treatment through rapid transcriptional regulation

Frontiers in Cellular and Infection Microbiology
IntroductionHeteroresistance is a well-known phenomenon contributing to treatment failure in bacterial infections. Previous research has traditionally linked it to genetic mechanisms, emphasizing fixed subpopulations with specific resistance mutations ...
YunTao Luo, Rong Xu, Bo Yuan, WeiHua Yang, YunHeng Zhou, Yuan Tian, QingZhong Wang   +6 more
doaj   +1 more source

Investigation of colistin heteroresistance and the colistin resistance genes mcr-1 to mcr-5 in Escherichia coli and Klebsiella pneumoniae isolates in a tertiary hospital in Turkey

Journal of Infection in Developing Countries
Introduction: Heteroresistance is not detected by traditional antimicrobial susceptibility testing methods and may lead to treatment failures. Investigating the presence of plasmid-mediated colistin resistance genes is important because of the ...
Erkut Afyoncu, Canan Eryıldız
doaj   +1 more source

Investigation of bedaquiline heteroresistance among Mycobacterium tuberculosis isolates from Pakistan

Microbiology Spectrum
Bedaquiline is a key drug recommended by the WHO for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB, and its use could potentially shorten treatment duration with improved outcomes.
Faiqa Rashid, Shaukat Iqbal, Sabira Tahseen, Yanlin Zhao   +3 more
doaj   +1 more source

Placing in-vitro heteroresistance in the context of clinical results [PDF]

The Lancet Infectious Diseases, 2021
Matteo, Bassetti, Roger, Echols, Andrew, Koren, Andreas, Karas, Chris, Longshaw, Yoshinori, Yamano, Tsutae, Den Nagata   +6 more
openaire   +2 more sources