Results 101 to 110 of about 3,968 (183)

Mixed Mycobacterium tuberculosis-Strain Infections Are Associated With Poor Treatment Outcomes Among Patients With Newly Diagnosed Tuberculosis, Independent of Pretreatment Heteroresistance. [PDF]

, 2018
BackgroundHeteroresistant Mycobacterium tuberculosis infections (defined as concomitant infection with drug-resistant and drug-susceptible strains) may explain the higher risk of poor tuberculosis treatment outcomes observed among patients with mixed ...
Baik, Yeonsoo, Warren, Robin M, Modongo, Chawangwa, Shin, Sanghyuk S, Colman, Rebecca E, Allender, Christopher, Engelthaler, David M, Lemmer, Darrin, Zetola, Nicola M   +8 more
core   +1 more source

Heteroresistance to carbapenems in Acinetobacter baumannii [PDF]

Journal of Antimicrobial Chemotherapy, 2005
S, Pournaras, A, Ikonomidis, A, Markogiannakis, A N, Maniatis, A, Tsakris   +4 more
openaire   +2 more sources

A Birth-Death Model to Understand Bacterial Antimicrobial Heteroresistance from Time-Kill Curves. Matlab Codes

The repository consists of the following main files: - MainSSA.m: The main script where the user define the options (number of trajectories, parameter values, simulation times, antimicrobial concentrations, etc.) for simulating stochastic trajectories ...
Martínez-López, Nerea, Vilas Fernández, Carlos, García, Miriam R.   +2 more
core   +1 more source

Machine learning detection of heteroresistance in Escherichia coli

eBioMedicine
Heteroresistance (HR) is a significant type of antibiotic resistance observed for several bacterial species and antibiotic classes where a susceptible main population contains small subpopulations of resistant cells. Mathematical models, animal experiments and clinical studies associate HR with treatment failure.
Andrei Guliaev, Karin Hjort, Michele Rossi, Sofia Jonsson, Hervé Nicoloff, Lionel Guy, Dan I. Andersson   +6 more
openaire   +3 more sources

Antibiotic susceptibility, heteroresistance, and updated treatment strategies in Helicobacter pylori infection

, 2017
Maria Teresa Mascellino,1 Barbara Porowska,2 Massimiliano De Angelis,1 Alessandra Oliva1 1Department of Public Health and Infectious Diseases, 2Department of Cardio-Thoracic, Vascular, General Surgery and of Organ Transplants, Policlinico Umberto I ...
Porowska B, De Angelis M, Mascellino MT, Oliva A   +3 more
core  

The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing

Nature Communications
Antibiotic heteroresistance, characterized by rare resistant subpopulations of bacteria within a susceptible main population, is associated with treatment failure and often caused by tandem amplification of resistance genes. Here, we investigated how the
Sofia Jonsson, Andrei Guliaev, Brandon A. Berryhill, Dan I. Andersson, Hervé Nicoloff   +4 more
doaj   +1 more source

Population size modulates the transition from gene amplification-mediated heteroresistance to stable resistance

npj Antimicrobials and Resistance
Heteroresistance is characterized by antibiotic-resistant subpopulations which can be underpinned by reversible gene duplication-amplification (GDA) of antibiotic resistance genes. It is often considered a precursor of stable resistance mutations.
Johannes Kupke, Yuwen Fang, Fereshteh Ghazisaeedi, Dennis Hanke, Frank Schreiber, Karsten Tedin, Niclas Nordholt, Marcus Fulde   +7 more
doaj   +1 more source

Heteroresistance is associated with mutations during low concentration of tigecycline therapy in multiple-resistant Klebsiella pneumoniae

Annals of Clinical Microbiology and Antimicrobials
Background Heteroresistance can lead to treatment failure and has brought a rigorous challenge to clinical laboratories for detecting them. The aim of this study was to investigate the potential for tigecycline-susceptible Klebsiella pneumoniae (K ...
Qiaoyu Zhang, Linwen Zheng, Lirong Wen, Shanshan Li, Yuli Nie, Jiansen Chen   +5 more
doaj   +1 more source

A birth–death model to understand bacterial antimicrobial heteroresistance from time-kill curves

15 pages, 2 tables, 4 figures.-- Under a Creative Commons licenseAntimicrobial heteroresistance refers to the presence of different subpopulations with heterogeneous antimicrobial responses within the same bacterial isolate, so they show reduced ...
Martínez-López, Nerea, Vilas Fernández, Carlos, García, Miriam R.   +2 more
core   +1 more source

Genetic Evaluation of Heteroresistance among Carbapenem-Susceptible Clinical Isolates of Enterobacterales

Canadian Journal of Infectious Diseases and Medical Microbiology
Carbapenems currently serve as the last line of defense when treating serious infections caused by multidrug-resistant Enterobacterales species; however, heteroresistance of these species is thought to cause failure in the treatment with these broad ...
İpek Koçer, Mehmet Eri̇nmez, Yasemin Zer   +2 more
doaj   +1 more source