Results 111 to 120 of about 5,136 (212)

Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia [PDF]

, 2013
A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥ 400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin ...
Antibiotic Expert Group, Benjamin P. Howden, Brown, Charles, Charlson, Clinical and Laboratory Standards Institute, Cockcroft, Craig, Craig, del Mar Fernandez de Gatta Garcia, Deresinski, Drusano, Gould, Hidayat, Holland, Holmes, Holmes, Howden, Hsu, J. Owen Robinson, Jeffres, John D. Turnidge, Knaus, Kullar, Le Gall, Lodise, Lodise, Mathew, Mathew, Matthew V. N. O'Sullivan, McGregor, Mohr, Moise, Moise, Moise-Broder, Musta, Natasha E. Holmes, Neuner, Paterson, Paul D. R. Johnson, Prakash, Price, Rehm, Rose, Rule, Rybak, Rybak, Sader, Sakoulas, Sally A. Roberts, Sanchia J. C. Warren, Soriano, Tara L. Anderson, Tony M. Korman, van Hal, van Hal, Wei Gao, Wendy J. Munckhof   +57 more
core   +1 more source

Tandem amplification of the umpA allele contributes to ceftazidime-avibactam heteroresistance in clinical carbapenem-resistant Klebsiella pneumoniae isolates

Microbiology Spectrum
Ceftazidime-avibactam (CAZ/AVI, CZA) combination has shown promising efficacy against carbapenem-resistant Klebsiella pneumoniae (CRKP); however, several recent studies have reported resistance to CZA in CRKP.
Mengyao Wang, Ying Li, Jia Hu, Yu Zhang, Jing Yu, Feng Li, Yuqiao Han, Yuyuan Li, Tao Song, Yiling Lin, Yang Chen   +10 more
doaj   +1 more source

Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance

npj Antimicrobials and Resistance
Bacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases.
Linna Xu, Xiaofen Mo, Hui Zhang, Fen Wan, Qixia Luo, Yonghong Xiao   +5 more
doaj   +1 more source

Aminoglycoside Heteroresistance in Acinetobacter baumannii AB5075

mSphere, 2018
Acinetobacter baumannii has become an important pathogen in hospitals worldwide, where the incidence of these infections has been increasing. A. baumannii infections have become exceedingly difficult to treat due to a rapid increase in the frequency of multidrug- and pan-resistant isolates.
Sarah E. Anderson, Edgar X. Sherman, David S. Weiss, Philip N. Rather   +3 more
openaire   +3 more sources

Approaches for identifying and measuring heteroresistance in azole-susceptible Candida isolates

Microbiology Spectrum
Heteroresistance to antifungal agents poses a significant challenge in the treatment of fungal infections. Currently, the absence of established methods for detecting and measuring heteroresistance impedes progress in understanding this phenomenon in ...
Cécile Gautier, Eli I. Maciel, Iuliana V. Ene   +2 more
doaj   +1 more source

Mycobacterium tuberculosis and whole genome sequencing: a practical guide and online tools available for the clinical microbiologist [PDF]

, 2017
Whole genome sequencing (WGS) has the potential to revolutionize the diagnosis of Mycobacterium tuberculosis (MTB) but the lack of bioinformatic expertise among clinical microbiologists is a barrier for adoption.
Atzeni, A, McHugh, TD, Satta, G
core   +1 more source

Clinical, Microbiological, and Genetic Characteristics of Heteroresistant Vancomycin-Intermediate Staphylococcus aureus Bacteremia in a Teaching Hospital [PDF]

, 2014
The emergence of vancomycin intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) is of major concern worldwide. Our objective was to investigate the prevalence, phenotypic and molecular features of hVISA strains isolated from ...
de Gregorio, Stella, Di Gregorio, Sabrina Noelia, Famiglietti, Angela María Rosa, Focoli, Mónica, Garcia, Susana, Lasala, María Beatriz, Martinez Ordoñez, Andrea, Mollerach, Marta Eugenia, Perazzi, Beatriz Elizabeth, Vay, Carlos Alberto   +9 more
core   +1 more source

Helicobacter pylori and Its Antibiotic Heteroresistance: A Neglected Issue in Published Guidelines

Frontiers in Microbiology, 2019
“Heteroresistance” is a widely applied term that characterizes most of the multidrug-resistant microorganisms. In microbiological practice, the word “heteroresistance” indicates diverse responses to specific antibiotics by bacterial subpopulations in the
Albert A. Rizvanov, Thomas Haertlé, Thomas Haertlé, Thomas Haertlé, Lydia Bogomolnaya, Lydia Bogomolnaya, Amin Talebi Bezmin Abadi   +6 more
doaj   +1 more source

Comparison of Real-Time PCR with Disk Diffusion, Agar Screen and E-test Methods for Detection of Methicillin-Resistant Staphylococcus aureus [PDF]

, 2010
Methicillin-resistant Staphylococcus aureus (MRSA) is a nosocomial pathogen. Our main objective was to compare oxacillin disk test, oxacillin E-test, and oxacillin agar screen for detection of methicillin resistance in S.
Karimi, Ali., Nafisi, Mohammad Reza., Shariati, Laleh., Tabatabaiefar, Mohammad Amin., Validi, Majid.   +4 more
core   +1 more source

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. [PDF]

, 2017
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia.
Atre, Sachin R, Chang, Kwok Chiu, Churchyard, Gavin J, Clark, Taane G, Dheda, Keertan, Dooley, Kelly E, Dowdy, David, Esmail, Aliasgar, Fennelly, Kevin P, Furin, Jennifer, Goemaere, Eric, Gumbo, Tawanda, Hesseling, Anneke C, Horsburgh, C Robert, Jara, Carolina Morán, Jaramillo, Ernesto, Lange, Christoph, Lessem, Erica, Lin, Hsien-Ho, London, Leslie, Low, Marcus, Maartens, Gary, McIlleron, Helen, McNerney, Ruth, Menzies, Dick, Merker, Matthias, Murray, Megan, Nahid, Payam, Nardell, Edward A, Niemann, Stefan, Nuermberger, Eric, Padayatchi, Nesri, Pasipanodya, Jotam G, Rodrigues, Camilla, Schaaf, H Simon, Sirgel, Frik A, Siu, Gilman KH, Theron, Grant, Udwadia, Zarir F, van Helden, Paul, Van Rie, Annelies, Warren, Robin M   +41 more
core   +1 more source