Results 111 to 120 of about 3,968 (183)

Heterogeneous subpopulations in Escherichia coli strains acquire adaptive resistance to imipenem treatment through rapid transcriptional regulation

Frontiers in Cellular and Infection Microbiology
IntroductionHeteroresistance is a well-known phenomenon contributing to treatment failure in bacterial infections. Previous research has traditionally linked it to genetic mechanisms, emphasizing fixed subpopulations with specific resistance mutations ...
YunTao Luo, Rong Xu, Bo Yuan, WeiHua Yang, YunHeng Zhou, Yuan Tian, QingZhong Wang   +6 more
doaj   +1 more source

Investigation of colistin heteroresistance and the colistin resistance genes mcr-1 to mcr-5 in Escherichia coli and Klebsiella pneumoniae isolates in a tertiary hospital in Turkey

Journal of Infection in Developing Countries
Introduction: Heteroresistance is not detected by traditional antimicrobial susceptibility testing methods and may lead to treatment failures. Investigating the presence of plasmid-mediated colistin resistance genes is important because of the ...
Erkut Afyoncu, Canan Eryıldız
doaj   +1 more source

Biodiversity of heteroresistance in food spoilage microorganisms

Spoilage of food by microorganisms is a growing problem in food supply chains. Food preservation methods are employed to prevent microbial spoilage of food, however the efficacy of these preservatives is challenged by specialised species which can grow ...

core   +1 more source

Investigation of bedaquiline heteroresistance among Mycobacterium tuberculosis isolates from Pakistan

Bedaquiline is a key drug recommended by the WHO for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB, and its use could potentially shorten treatment duration with improved outcomes.
Faiqa Rashid, Shaukat Iqbal, Yanlin Zhao, Sabira Tahseen   +3 more
core   +1 more source

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification

, 2019
When choosing antibiotics to treat bacterial infections, it is assumed that the susceptibility of the target bacteria to an antibiotic is reflected by laboratory estimates of the minimum inhibitory concentration (MIC) needed to prevent bacterial growth ...
Hjort, Karin,, Nicoloff, Hervé,, Levin, Bruce R.,, Andersson, Dan I,   +3 more
core   +1 more source

Placing in-vitro heteroresistance in the context of clinical results [PDF]

The Lancet Infectious Diseases, 2021
Matteo, Bassetti, Roger, Echols, Andrew, Koren, Andreas, Karas, Chris, Longshaw, Yoshinori, Yamano, Tsutae, Den Nagata   +6 more
openaire   +2 more sources

Spread of an MRSA clone with heteroresistance to oxacillin in the Netherlands

Eurosurveillance, 2002
Since 2001, an increase in the number of MRSA strains with heteroresistance to oxacillin has been observed in the Netherlands. These strains can spread unnoticed, as their phenotypic heterogenous resistance to beta-lactams affects the results of susceptibility testing. Therefore, further testing using PBP2a latex agglutination or PCR are recommended.
openaire   +2 more sources

Study of the mechanisms of colistin heteroresistance in a strain of Enterobacter cloacae by random mutagenesis

Objective: The Enterobacter cloacae complex belongs to a group in which colistin resistance is not well documented due to their frequent heteroresistance. Methods: We investigated the molecular basis of colistin heteroresistance using genome analysis and
Linda Hadjadj, Baron, Sophie Alexandra, Hadjadj, Linda, Jean-Marc Rolain, Romane Milleville, Sophie Alexandra Baron, Milleville, Romane, Rolain, Jean-Marc   +7 more
core   +1 more source

Heteroresistance [PDF]

, 2012
openaire   +1 more source

Frequency of cefiderocol heteroresistance among patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections

Background: Cefiderocol exhibits potent in vitro activity against carbapenem-resistant Acinetobacter baumannii (CRAb), but this activity has not consistently translated to improved outcomes among patients. Cefiderocol heteroresistance, or the presence of
Griffith, Marissa P, Tiseo, Giusy, Barnini, Simona, Shields, Ryan K, Giordano, Cesira, Dorazio, Ava J, Squires, Kevin M, Doi, Yohei, Leonildi, Alessandro, Van Tyne, Daria, Kline, Ellen G, Falcone, Marco, Iovleva, Alina   +12 more
core   +1 more source