Results 131 to 140 of about 5,136 (212)

Machine learning detection of heteroresistance in Escherichia coli

eBioMedicine
Heteroresistance (HR) is a significant type of antibiotic resistance observed for several bacterial species and antibiotic classes where a susceptible main population contains small subpopulations of resistant cells. Mathematical models, animal experiments and clinical studies associate HR with treatment failure.
Andrei Guliaev, Karin Hjort, Michele Rossi, Sofia Jonsson, Hervé Nicoloff, Lionel Guy, Dan I. Andersson   +6 more
openaire   +3 more sources

Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance

Nature Communications
Heteroresistance is a medically relevant phenotype where small antibiotic-resistant subpopulations coexist within predominantly susceptible bacterial populations. Heteroresistance reduces treatment efficacy across diverse bacterial species and antibiotic
Hervé Nicoloff, Karin Hjort, Dan I. Andersson, Helen Wang   +3 more
doaj   +1 more source

Heterogeneous subpopulations in Escherichia coli strains acquire adaptive resistance to imipenem treatment through rapid transcriptional regulation

Frontiers in Cellular and Infection Microbiology
IntroductionHeteroresistance is a well-known phenomenon contributing to treatment failure in bacterial infections. Previous research has traditionally linked it to genetic mechanisms, emphasizing fixed subpopulations with specific resistance mutations ...
YunTao Luo, Rong Xu, Bo Yuan, WeiHua Yang, YunHeng Zhou, Yuan Tian, QingZhong Wang   +6 more
doaj   +1 more source

Emerging infectious diseases in Hong Kong. [PDF]

, 2001
published_or_final_versio
Yuen, KY
core  

Investigation of colistin heteroresistance and the colistin resistance genes mcr-1 to mcr-5 in Escherichia coli and Klebsiella pneumoniae isolates in a tertiary hospital in Turkey

Journal of Infection in Developing Countries
Introduction: Heteroresistance is not detected by traditional antimicrobial susceptibility testing methods and may lead to treatment failures. Investigating the presence of plasmid-mediated colistin resistance genes is important because of the ...
Erkut Afyoncu, Canan Eryıldız
doaj   +1 more source

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study [PDF]

, 2017
Objectives Treatment outcome of MDR-TB is critically dependent on the proper use of second-line drugs as per the result of in vitro drug susceptibility testing (DST).
Böttger, E. C., Cambau, E., Cirillo, D. M., Hoffner, S., Machado, D., Matthys, V., Perez Del Molino, M. L., Raskine, L., Richter, E., Ritter, C., Tortoli, E., van Soolingen, D., Viveiros, M.   +12 more
core  

Investigation of bedaquiline heteroresistance among Mycobacterium tuberculosis isolates from Pakistan

Microbiology Spectrum
Bedaquiline is a key drug recommended by the WHO for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB, and its use could potentially shorten treatment duration with improved outcomes.
Faiqa Rashid, Shaukat Iqbal, Sabira Tahseen, Yanlin Zhao   +3 more
doaj   +1 more source

Rapid identification of a Mycobacterium tuberculosis full genetic drug resistance profile through whole genome sequencing directly from sputum [PDF]

, 2017
INTRODUCTION: Resistance to second line tuberculosis drugs is common, but slow to diagnose with phenotypic drug sensitivity testing. Rapid molecular tests speed up diagnosis, but can only detect limited mutations.
Booth, H, Breuer, J, Brown, M, Burgess, C, Doyle, R, Gorton, R, McHugh, TD, Morris-Jones, S, Nimmo, C, Williams, R   +9 more
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Resistance and Heteroresistance to Colistin in Escherichia coli Isolates from Wenzhou, China

Infection and Drug Resistance, 2020
Wenli Liao,1,* Jie Lin,2,* Huaiyu Jia,1 Cui Zhou,1 Ying Zhang,3 Yishuai Lin,3 Jianzhong Ye,1 Jianming Cao,3 Tieli Zhou1 1Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People ...
Liao W, Lin J, Jia H, Zhou C, Zhang Y, Lin Y, Ye J, Cao J, Zhou T   +8 more
doaj  

Impact of sar and agr on methicillin resistance in Staphylococcus aureus [PDF]

, 2017
The global regulators agr and sar control expression of cell wall and extracellular proteins. Inactivation of either sar and/or agr in a typical heterogeneously methicillin-resistant Staphylococcus aureus resulted in a small but reproducible decrease in ...
Berger-Bächi, B., Durán, S.Píriz, Kayser, F.H.   +2 more
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