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Mechanisms and clinical relevance of bacterial heteroresistance
Nature Reviews Microbiology, 2019Antibiotic heteroresistance is a phenotype in which a bacterial isolate contains subpopulations of cells that show a substantial reduction in antibiotic susceptibility compared with the main population. Recent work indicates that heteroresistance is very common for several different bacterial species and antibiotic classes.
Dan Andersson +2 more
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Emergence of Heteroresistance Mycobacterium Tuberculosis in Saudi Arabia
Infectious Disorders - Drug Targets, 2020Purpose:Heteroresistant Mycobacterium tuberculosis (MTB) is defined as a group of drug-susceptible and resistant bacteria in a single clinical specimen from tuberculosis (TB) patients. Heteroresistance of MTB is considered a preliminary stage to full resistance.
Eltayib H Ahmed, Abakur +4 more
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Heteroresistance in Mycobacterium tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2001Drug resistance in Mycobacterium tuberculosis is often linked to specific mutations in a limited number of resistance genes. Detection of these mutations in a cultured isolate can predict the resistant phenotype. Genotypic analysis of the mycobacteria directly in a clinical specimen would result in considerable time saving for resistance prediction.To ...
H, Rinder, K T, Mieskes, T, Löscher
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Heteroresistance: A Harbinger of Future Resistance
2018During infection, bacterial populations often contain subpopulations that exhibit reduced antimicrobial susceptibility. The resulting population heterogeneity is called heteroresistance. Since a heteroresistant population can evolve into a resistant one, a heteroresistant infection is a risk factor for the development of complete resistance.
Karl Drlica, Bo Shopsin, Xilin Zhao
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Intrinsic clarithromycin heteroresistance in Mycobacterium avium
Journal of Infection and ChemotherapyMycobacterium avium is associated with pulmonary disease in otherwise healthy adults. Several clarithromycin-refractory cases have been reported, including some cases caused by clarithromycin-susceptible strains.To characterize the reason for the discrepancy between clinical response and antibiotic susceptibility results.We conducted population ...
Ai Ito +9 more
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Outcome of Heteroresistant Staphylococcus aureus Infections in Children
Journal of Infectious Diseases, 1987Strains of Staphylococcus aureus may display heterogeneous resistance to penicillinase-resistant penicillins in vitro [1-3]. These strains contain methicillin-susceptible organisms that have the usual characteristics of nonheteroresistant S. aureus and methicillin-resistant organisms, which grow more slowly and may escape detection under ordinary ...
M W, Kline, E O, Mason, S L, Kaplan
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Antibiotic heteroresistance in ESKAPE pathogens, from bench to bedside
Clinical Microbiology and Infection, 2023Roberto Sierra +2 more
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Lesion Heterogeneity and Long-Term Heteroresistance in Multidrug-Resistant Tuberculosis
Journal of Infectious Diseases, 2021Howard Takiff, Qingyun Liu, Qi Jiang
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