Results 161 to 170 of about 3,968 (183)
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Heteroresistance to Cefepime in Pseudomonas aeruginosa Bacteraemia
International Journal of Antimicrobial Agents, 2020Heteroresistance to antibiotic agents can lead to diagnostic and therapeutic failures; however, to date, cefepime heteroresistance (FEP-HR) in Pseudomonas aeruginosa (P. aeruginosa) bacteraemia has not been characterised. The primary goal of this study was to investigate the molecular epidemiology, mechanisms and risk factors for cefepime ...
Xiaojiong Jia +2 more
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Antibiotic Heteroresistance in Klebsiella pneumoniae
International Journal of Molecular Sciences, 2022 Klebsiella pneumoniae is one of the most common pathogens responsible for infections, including pneumonia, urinary tract infections, and bacteremias. The increasing prevalence of multidrug-resistant K. pneumoniae was recognized in 2017 by the World Health Organization as a critical public health threat.
Karolina Stojowska-Swędrzyńska +2 more
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Mycoses, 2017
SummaryThe concept of heteroresistance refers to the heterogeneous susceptibility to an antimicrobial drug in a microorganism population, meaning that some clones may be resistant and others are susceptible. This phenomenon has been widely studied in bacteria, but little attention has been given to its expression in fungi.
Gabriella F Ferreira, Daniel A Santos
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SummaryThe concept of heteroresistance refers to the heterogeneous susceptibility to an antimicrobial drug in a microorganism population, meaning that some clones may be resistant and others are susceptible. This phenomenon has been widely studied in bacteria, but little attention has been given to its expression in fungi.
Gabriella F Ferreira, Daniel A Santos
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Mechanisms and Clinical Relevance of Bacterial Heteroresistance
Nature Reviews Microbiology, 2019Antibiotic heteroresistance is a phenotype in which a bacterial isolate contains subpopulations of cells that show a substantial reduction in antibiotic susceptibility compared with the main population. Recent work indicates that heteroresistance is very common for several different bacterial species and antibiotic classes.
Dan Andersson +2 more
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Proceedings of the National Academy of Sciences of the United States of AmericaAntibiotics are considered one of the most important contributions to clinical medicine in the last century. Due to the use and overuse of these drugs, there have been increasing frequencies of infections with resistant pathogens. One form of resistance,
Dan Andersson +2 more
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Heteroresistance in Mycobacterium tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2001Drug resistance in Mycobacterium tuberculosis is often linked to specific mutations in a limited number of resistance genes. Detection of these mutations in a cultured isolate can predict the resistant phenotype. Genotypic analysis of the mycobacteria directly in a clinical specimen would result in considerable time saving for resistance prediction.To ...
H, Rinder, K T, Mieskes, T, Löscher
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Heteroresistance: A Harbinger of Future Resistance
2018During infection, bacterial populations often contain subpopulations that exhibit reduced antimicrobial susceptibility. The resulting population heterogeneity is called heteroresistance. Since a heteroresistant population can evolve into a resistant one, a heteroresistant infection is a risk factor for the development of complete resistance.
Karl Drlica, Bo Shopsin, Xilin Zhao
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Intrinsic clarithromycin heteroresistance in Mycobacterium avium
Journal of Infection and ChemotherapyMycobacterium avium is associated with pulmonary disease in otherwise healthy adults. Several clarithromycin-refractory cases have been reported, including some cases caused by clarithromycin-susceptible strains.To characterize the reason for the discrepancy between clinical response and antibiotic susceptibility results.We conducted population ...
Ai Ito +9 more
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Outcome of Heteroresistant Staphylococcus aureus Infections in Children
Journal of Infectious Diseases, 1987Strains of Staphylococcus aureus may display heterogeneous resistance to penicillinase-resistant penicillins in vitro [1-3]. These strains contain methicillin-susceptible organisms that have the usual characteristics of nonheteroresistant S. aureus and methicillin-resistant organisms, which grow more slowly and may escape detection under ordinary ...
M W, Kline, E O, Mason, S L, Kaplan
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