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Helicobacter pylori and Its Antibiotic Heteroresistance: A Neglected Issue in Published Guidelines
Frontiers in Microbiology, 2019 “Heteroresistance” is a widely applied term that characterizes most of the multidrug-resistant microorganisms. In microbiological practice, the word “heteroresistance” indicates diverse responses to specific antibiotics by bacterial subpopulations in the
Albert A. Rizvanov +6 more
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Nature CommunicationsHeteroresistance is a medically relevant phenotype where small antibiotic-resistant subpopulations coexist within predominantly susceptible bacterial populations. Heteroresistance reduces treatment efficacy across diverse bacterial species and antibiotic
Hervé Nicoloff +3 more
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Polymyxin heteroresistance in <i>Klebsiella oxytoca</i>. [PDF]
J Med MicrobiolIntroduction. Antibiotic heteroresistance presents a growing public health concern, as the phenotype is associated with treatment failure and is hard to detect using conventional diagnostic testing. Gap Statement. Heteroresistance in
Ayerakwa EA +4 more
europepmc +3 more sources
Ceftaroline-Heteroresistant Staphylococcus aureus [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT Heteroresistance refers to the presence, within a large population of antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibilities. Ceftaroline is a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA).
Stephanie N, Saravolatz +4 more
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Detection of Heteroresistant Mycobacterium tuberculosis by Pyrosequencing [PDF]
Journal of Clinical Microbiology, 2013 ABSTRACT The ability of pyrosequencing to detect a resistant minority population of a heteroresistant Mycobacterium tuberculosis strain was investigated by performing a titration study. A mutant signal was noted only when the proportion of mutant DNA in the DNA target was 35 to 50%, showing that the ...
Anna, Engström +2 more
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Heteroresistance to Fluconazole and Voriconazole in Cryptococcus neoformans [PDF]
Antimicrobial Agents and Chemotherapy, 1999 ABSTRACT Cryptococcus neoformans isolates that exhibited unusual patterns of resistance to fluconazole and voriconazole were isolated from seven isolates from two different geographical regions: one isolate from an Israeli non-AIDS patient and six serial isolates from an Italian AIDS patient who had suffered six ...
Mondon P. +6 more
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Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis
Antimicrobial Agents and Chemotherapy, 2021 Heteroresistance is defined as the coexistence of both susceptible and resistant bacteria in a bacterial population. Previously published data show that it may occur in 9 to 57% of Mycobacterium tuberculosis isolates for various drugs.
Jim Werngren +4 more
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Heteroresistance to Cephalosporins and Penicillins in Acinetobacter baumannii [PDF]
Journal of Clinical Microbiology, 2012 ABSTRACT Heteroresistance to antimicrobial agents may affect susceptibility test results and therapeutic success. In this study, we investigated heteroresistance to cephalosporins and penicillins in Acinetobacter baumannii , a major pathogen causing nosocomial infections. Two A. baumannii
Kuei-Hsiang, Hung +4 more
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Frontiers in Cellular and Infection Microbiology, 2022 BackgroundAntimicrobial susceptibility testing (AST) plays a vital role in anti-Helicobacter pylori treatment, but the traditional AST method has difficulty detecting heteroresistance, which may cause an increased prevalence of resistant strains and ...
You-hua Wang +7 more
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Colistin heteroresistance, mechanisms, diagnostic methods, and therapeutic options: A review. [PDF]
GermsThe heteroresistance phenotype refers to the presence of bacterial subpopulations with reduced antibiotic susceptibility compared with the main population. Mathematical modelling and computer simulations suggest that heteroresistance can lead to negative
Dehbanipour R, Maleki VTZ, Ghalavand Z.
europepmc +2 more sources