Results 41 to 50 of about 3,808 (178)
Microbiology SpectrumBedaquiline is a key drug recommended by the WHO for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB, and its use could potentially shorten treatment duration with improved outcomes.
Faiqa Rashid +3 more
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Nature CommunicationsHeteroresistance is a medically relevant phenotype where small antibiotic-resistant subpopulations coexist within predominantly susceptible bacterial populations. Heteroresistance reduces treatment efficacy across diverse bacterial species and antibiotic
Hervé Nicoloff +3 more
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Ceftaroline-Heteroresistant Staphylococcus aureus [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT Heteroresistance refers to the presence, within a large population of antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibilities. Ceftaroline is a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA).
Stephanie N, Saravolatz +4 more
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Detection of Heteroresistant Mycobacterium tuberculosis by Pyrosequencing [PDF]
Journal of Clinical Microbiology, 2013 ABSTRACT The ability of pyrosequencing to detect a resistant minority population of a heteroresistant Mycobacterium tuberculosis strain was investigated by performing a titration study. A mutant signal was noted only when the proportion of mutant DNA in the DNA target was 35 to 50%, showing that the ...
Anna, Engström +2 more
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Heteroresistance to Cephalosporins and Penicillins in Acinetobacter baumannii [PDF]
Journal of Clinical Microbiology, 2012 ABSTRACT Heteroresistance to antimicrobial agents may affect susceptibility test results and therapeutic success. In this study, we investigated heteroresistance to cephalosporins and penicillins in Acinetobacter baumannii , a major pathogen causing nosocomial infections. Two A. baumannii
Kuei-Hsiang, Hung +4 more
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Heteroresistance to Fluconazole and Voriconazole in Cryptococcus neoformans [PDF]
Antimicrobial Agents and Chemotherapy, 1999 ABSTRACT Cryptococcus neoformans isolates that exhibited unusual patterns of resistance to fluconazole and voriconazole were isolated from seven isolates from two different geographical regions: one isolate from an Israeli non-AIDS patient and six serial isolates from an Italian AIDS patient who had suffered six ...
Mondon P. +6 more
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Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis
Antimicrobial Agents and Chemotherapy, 2021 Heteroresistance is defined as the coexistence of both susceptible and resistant bacteria in a bacterial population. Previously published data show that it may occur in 9 to 57% of Mycobacterium tuberculosis isolates for various drugs.
Jim Werngren +4 more
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Frontiers in Cellular and Infection Microbiology, 2022 BackgroundAntimicrobial susceptibility testing (AST) plays a vital role in anti-Helicobacter pylori treatment, but the traditional AST method has difficulty detecting heteroresistance, which may cause an increased prevalence of resistant strains and ...
You-hua Wang +7 more
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Bacterial Cooperation Leads to Heteroresistance
DEStech Transactions on Computer Science and Engineering, 2018 By challenging E. coli with sublethal norfloxacin for 10 days, Henry Lee and James Collins suggests the bacterial altruism leads to the population-wide resistance. By detailedly analyzing experiment data, we suggest that bacterial cooperation leads to population-wide resistance under norfloxacin pressure and simultaneously propose the bacteria shield ...
Xu, Shilian, Yang, Jiaru, Yin, Chong
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Heteroresistance to Vancomycin in Enterococcus faecium [PDF]
Journal of Clinical Microbiology, 2001 ABSTRACT This study presents the first report of vancomycin heteroresistance in an Enterococcus faecium isolate from a patient. The original isolate was susceptible in vitro to vancomycin. E-tests showed growth of subcolonies in a zone of inhibition with a vancomycin MIC of >256 μg/ml.
M R, Alam +6 more
openaire +2 more sources