Quorum sensing regulates heteroresistance in Pseudomonas aeruginosa
Frontiers in Microbiology, 2022 The prevalence and genetic mechanism of antibiotic heteroresistance (HR) have attracted significant research attention recently. However, non-genetic mechanism of HR has not been adequately explored. The present study aimed to evaluate the role of quorum sensing (QS), an important mechanism of behavioral coordination in different subpopulations and ...
Yang Lu +12 more
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Heteroresistance to Vancomycin in Enterococcus faecium [PDF]
Journal of Clinical Microbiology, 2001 ABSTRACT This study presents the first report of vancomycin heteroresistance in an Enterococcus faecium isolate from a patient. The original isolate was susceptible in vitro to vancomycin. E-tests showed growth of subcolonies in a zone of inhibition with a vancomycin MIC of >256 μg/ml.
M R, Alam +6 more
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Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement
Frontiers in Cellular and Infection Microbiology, 2022 With tuberculosis, the emergence of fluoroquinolone resistance erodes the ability of treatment to interrupt the progression of MDR-TB to XDR-TB. One way to reduce the emergence of resistance is to identify heteroresistant infections in which subpopulations of resistant mutants are likely to expand and make the infections fully resistant: treatment ...
Amit Singh +4 more
openaire +3 more sources
Two types of colistin heteroresistance in Acinetobacter baumannii isolates
Emerging Microbes and Infections, 2020 In this study, we investigated the colistin heteroresistance patterns in Acinetobacter baumannii isolates. To identify colistin heteroresistance, population analysis profiling was performed for six in vitro colistin-susceptible A.
Yoon-Kyoung Hong +2 more
doaj +1 more source
A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis. [PDF]
, 2017 Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases.
Catanzaro, A +7 more
core +1 more source
Heteroresistance to penicillin in Streptococcus pneumoniae [PDF]
Proceedings of the National Academy of Sciences, 2007 Heteroresistance to β-lactam antibiotics has been mainly described for staphylococci, for which it complicates diagnostic procedures and therapeutic success. This study investigated whether heteroresistance to penicillin exists in Streptococcus pneumoniae .
Brigitte, Morand, Kathrin, Mühlemann
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Mechanism of Eravacycline Resistance in Clinical Enterococcus faecalis Isolates From China
Frontiers in Microbiology, 2020 Opportunistic infections caused by multidrug-resistant Enterococcus faecalis strains are a significant clinical challenge. Eravacycline (Erava) is a synthetic fluorocycline structurally similar to tigecycline (Tige) that exhibits robust antimicrobial ...
Zewen Wen +13 more
doaj +1 more source
ClassTR: Classifying Within-Host Heterogeneity Based on Tandem Repeats with Application to Mycobacterium tuberculosis Infections. [PDF]
, 2015 Genomic tools have revealed genetically diverse pathogens within some hosts. Within-host pathogen diversity, which we refer to as "complex infection", is increasingly recognized as a determinant of treatment outcome for infections like tuberculosis ...
Chindelevitch, L +4 more
core +3 more sources
Heteroresistance of Cryptococcus gattii to Fluconazole [PDF]
Antimicrobial Agents and Chemotherapy, 2010 ABSTRACT We analyzed 71 clinical and environmental Cryptococcus gattii strains that had been isolated before or after the advent of azole antifungals to determine their level of heteroresistance to fluconazole (LHF). All strains of C.
A, Varma, K J, Kwon-Chung
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The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model [PDF]
, 2012 There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens.
Alan Forrest +64 more
core +1 more source