Results 41 to 50 of about 3,683,995 (257)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Klebsiella Species and Enterobacter cloacae Isolates Harboring blaOXA-181 and blaOXA-48: Resistome, Fitness Cost, and Plasmid Stability

Microbiology Spectrum, 2022
IncX3 and IncL plasmids have been named as catalysts advancing dissemination of blaOXA-181 and blaOXA-48 genes. However, their impact on the performance of host cells is vastly understudied. Genetic characteristics of blaOXA-48- and blaOXA-181-containing
Samiratu Mahazu, Isaac Prah, Yusuke Ota, Takaya Hayashi, Yoko Nukui, Masato Suzuki, Yoshihiko Hoshino, Yukihiro Akeda, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito   +11 more
doaj   +1 more source

Influence of surgery and rehabilitation conditioning on psychophysiological fitness [PDF]

, 2008
The purpose of this study was to assess changes in psychophysiological fitness following reconstructive knee surgery and early phase (2.5 months) physical rehabilitation. Nine patients (7 male, 2 female; mean age, 29.9 years) electing to undergo anterior
Bailey, A, Rees, D, Minshull, Claire, Bailey, A., Rees, D., Gleeson, N, Parfitt, G, Minshull, C, Parfitt, G., Gleeson, Nigel   +9 more
core  

Fitness test profiles in children aged 8-12 years old in Granada (Spain) [PDF]

, 2011
The aim of this study was to determine the effects of physical education in body composition and health-related fitness among boys and girls aged 8 to 12 years old in Granada (Spain) in a longitudinal, randomized study of 5 months.
Ricardo López, Francisco Javier Rojas, López García, Ricardo, Concepción Suárez-Llorca, Andreu Cabrera, Eliseo, Eliseo Andreu-Cabrera, Cepero González, Mar, López, Ricardo, Suárez Llorca, Concepción, Rojas Ruiz, Francisco Javier, Mar Cepero, Andreu-Cabrera, Eliseo   +11 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Plasmid-Mediated Bioaugmentation for the Bioremediation of Contaminated Soils

Frontiers in Microbiology, 2017
Bioaugmentation, or the inoculation of microorganisms (e.g., bacteria harboring the required catabolic genes) into soil to enhance the rate of contaminant degradation, has great potential for the bioremediation of soils contaminated with organic ...
Carlos Garbisu, Olatz Garaiyurrebaso, Lur Epelde, Elisabeth Grohmann, Itziar Alkorta   +4 more
doaj   +1 more source

Impact of mcr-1 on the Development of High Level Colistin Resistance in Klebsiella pneumoniae and Escherichia coli

Frontiers in Microbiology, 2021
Plasmid-mediated colistin resistance gene mcr-1 generally confers low-level resistance. The purpose of this study was to investigate the impact of mcr-1 on the development of high-level colistin resistance (HLCR) in Klebsiella pneumoniae and Escherichia ...
Xiao-Qing Zhu, Xiao-Qing Zhu, Yi-Yun Liu, Yi-Yun Liu, Renjie Wu, Renjie Wu, Haoliang Xun, Haoliang Xun, Jian Sun, Jian Sun, Jian Li, Yaoyu Feng, Yaoyu Feng, Jian-Hua Liu, Jian-Hua Liu   +14 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents

Frontiers in Microbiology, 2020
It is well-established that the spread of many multidrug-resistant (MDR) bacteria is predominantly clonal. Interestingly the international clones/sequence types (STs) of most pathogens emerged and disseminated during the last three decades.
Miklos Fuzi, Jesus Rodriguez Baño, Akos Toth   +2 more
doaj   +1 more source

Resistance to the SDHI Fungicides Boscalid and Fluopyram in Podosphaera xanthii Populations from Commercial Cucurbit Fields in Spain

Journal of Fungi, 2021
Powdery mildew is caused by Podosphaera xanthii, and is one of the most important diseases that attacks Spanish cucurbit crops. Fungicide application is the primary control tool; however, its effectiveness is hampered by the rapid development of ...
Alejandra Vielba-Fernández, Álvaro Polonio, Laura Ruiz-Jiménez, Antonio de Vicente, Alejandro Pérez-García, Dolores Fernández-Ortuño   +5 more
doaj   +1 more source