Results 51 to 60 of about 577,400 (301)

Sex allocation theory reveals a hidden cost of neonicotinoid exposure in a parasitoid wasp [PDF]

open access: yes, 2015
P.R.W. was funded by the University of Stirling, C.V.B. and S.M.G. were funded by Nuffield Research Placements and N.C., J.G. and D.M.S. were funded by NERC (NE/J024481/1).Sex allocation theory has proved to be one the most successful theories in ...
Blackburn, Charlotte V.   +6 more
core   +2 more sources

Fitness costs of resistance to antimalarial drugs

open access: yesTrends in Parasitology, 2008
It has been recently reported that the prevalence of mutations associated with chloroquine resistance declined during the dry season. Fitness costs of drug resistance were suggested to be responsible for reduced survival of mutant parasites, and only parasites surviving chronic infections were transmitted at the onset of the rainy season.
Felger Ingrid, Beck Hans-Peter
openaire   +3 more sources

Cost Effectiveness of Two Army Physical Fitness Programs [PDF]

open access: yesMilitary Medicine, 2013
Repeated failure in the Army Physical Fitness Test (APFT) is associated with lower fitness level, premature discharge, and significant career disruption, at high economic and health costs to the individual soldier and the U.S. Army. We used cost-effectiveness analysis to estimate the health and economic implications of two exercise interventions for ...
Laura A, Talbot   +4 more
openaire   +2 more sources

Fitness costs of CRISPR-Cas systems in bacteria

open access: yesMicrobiology, 2022
CRISPR-Cas systems provide bacteria with both specificity and adaptability in defence against invading genetic elements. From a theoretical perspective, CRISPR-Cas systems confer many benefits. However, they are observed at an unexpectedly low prevalence across the bacterial domain.
Michael Zaayman, Rachel M. Wheatley
openaire   +2 more sources

Pseudomonas aeruginosa heteroresistance to levofloxacin caused by upregulated expression of essential genes for DNA replication and repair

open access: yesFrontiers in Microbiology, 2022
Pseudomonas aeruginosa (P. aeruginosa), a common cause of severe chronic infections, has developed heteroresistance to several antibiotics, thus hindering successful treatment.
Wen-Ru Li   +7 more
doaj   +1 more source

The Cost of Laboratory Fittings [PDF]

open access: yesNature, 1920
IN all directions we have at the present time evidence of a growing enthusiasm for education in the field of natural science. Students are being turned away from our schools and universities for lack of accommodation, and the new Education Act has given great encouragement to science teaching.
openaire   +2 more sources

Environmentally induced development costs underlie fitness tradeoffs

open access: yesEcology, 2018
AbstractLocal adaptation can lead to genotype‐by‐environment interactions, which can create fitness tradeoffs in alternative environments, and govern the distribution of biodiversity across geographic landscapes. Exploring the ecological circumstances that promote the evolution of fitness tradeoffs requires identifying how natural selection operates ...
Walter, GM   +4 more
openaire   +4 more sources

In-vivo mutation rates and fitness landscape of HIV-1

open access: yes, 2016
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we
Albert, Jan   +4 more
core   +1 more source

Emergence and Mechanism of Resistance of Tulathromycin Against Mycoplasma hyopneumoniae in a PK/PD Model and the Fitness Costs of 23S rRNA Mutants

open access: yesFrontiers in Veterinary Science, 2022
Macrolides are widely used in diseases caused by Mycoplasma spp. The new semi-synthetic macrolide antibiotic tulathromycin is currently in wide use for the treatment of respiratory diseases of livestock.
Xirui Xia   +4 more
doaj   +1 more source

Predicting bacterial fitness cost associated with drug resistance [PDF]

open access: yesJournal of Antimicrobial Chemotherapy, 2012
It has been proposed that antimicrobial resistance could be associated with a fitness cost in bacteria, which is often determined by competition experiments between isogenic strains (wild-type and mutant). However, this conventional approach is time consuming and labour intensive.
Beining, Guo   +4 more
openaire   +2 more sources

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