Results 61 to 70 of about 577,400 (301)
Frontiers in Microbiology, 2022 Daptomycin is a last-line antibiotic used in the treatment of multidrug-resistant Enterococcus faecium infections. Alarmingly, daptomycin-resistant E. faecium isolates have emerged.
Weiliang Zeng +10 more
doaj +1 more source
Upon accounting for the impact of isoenzyme loss, gene deletion costs anticorrelate with their evolutionary rates [PDF]
, 2017 System-level metabolic network models enable the computation of growth and metabolic phenotypes from an organism’s genome. In particular, flux balance approaches have been used to estimate the contribution of individual metabolic genes to organismal ...
Jacobs, Christopher +3 more
core +4 more sources
, 2017 Much of our understanding of ecological and evolutionary mechanisms derives from analysis of low-dimensional models: with few interacting species, or few axes defining "fitness".
Monasson, Remi, Tikhonov, Mikhail
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim +8 more
wiley +1 more source
mBioAzoles are the primary antifungal drugs used to treat infections caused by Aspergillus fumigatus. However, the emergence of azole resistance in A. fumigatus has become a global health concern despite the low proportion of resistant isolates in natural ...
Shu Chen +8 more
doaj +1 more source
Pathogens, 2021 HIV cure studies require patients to enter an analytical treatment interruption (ATI). Here, we describe previously unanalyzed data that sheds light on ATI dynamics in PLHIV (People Living with HIV).
James R. Hunter +7 more
doaj +1 more source
Cognitive fitness of cost-efficient brain functional networks [PDF]
Proceedings of the National Academy of Sciences, 2009 The human brain's capacity for cognitive function is thought to depend on coordinated activity in sparsely connected, complex networks organized over many scales of space and time. Recent work has demonstrated that human brain networks constructed from neuroimaging data have economical small-world properties that confer high efficiency of information ...
Danielle S, Bassett +5 more
openaire +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
mSystemsThe global crisis of antimicrobial resistance poses a major threat to human health, underscoring the urgency of developing new antibacterial strategies.
Feiyu Yu +4 more
doaj +1 more source
The fitness costs of developmental canalization and plasticity [PDF]
Journal of Evolutionary Biology, 2009 AbstractOrganisms are capable of an astonishing repertoire of phenotypic responses to the environment, and these often define important adaptive solutions to heterogeneous and unpredictable conditions. The terms ‘phenotypic plasticity’ and ‘canalization’ indicate whether environmental variation has a large or small effect on the phenotype.
Van Buskirk, J, Steiner, U K
openaire +3 more sources