Results 81 to 90 of about 577,400 (301)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

War of attrition with implicit time cost [PDF]

, 2004
In the game-theoretic model war of attrition, players are subject to an explicit cost proportional to the duration of contests. We construct a model where the time cost is not explicitly given, but instead depends implicitly on the strategies of the ...
Eriksson, Anders, Lindgren, Kristian, Lundh, Torbjörn   +2 more
core   +3 more sources

A Small Multihost Plasmid Carrying erm(T) Identified in Enterococcus faecalis

Frontiers in Veterinary Science, 2022
The aim of this study was to determine the mobile genetic elements involved in the horizontal transfer of erm(T) in Enterococcus faecalis, and its transmission ability in heterologous hosts. A total of 159 erythromycin-resistant enterococci isolates were
Xing-Yun Li, Rui Yu, Chunyan Xu, Yanhong Shang, Dexi Li, Xiang-Dang Du   +5 more
doaj   +1 more source

The Comparison of Dual-Tasking and Functional Fitness in Older Females [PDF]

, 2016
Context: America’s aging population is growing faster than ever, resulting in increasing challenges for healthcare providers and caregivers. Over 33% of adults aged 65 and older fall annually, and falls are the number one cause of injury-related death in
Engler, Anna
core   +2 more sources

Transform Ranking: a New Method of Fitness Scaling in Genetic Algorithms [PDF]

, 2008
The first systematic evaluation of the effects of six existing forms of fitness scaling in genetic algorithms is presented alongside a new method called transform ranking.
A. O. Griewank, L. Nolle, V. Kreinovich
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A comparative analysis of Aedes albopictus and Aedes aegypti subjected to diapause-inducing conditions reveals conserved and divergent aspects associated with diapause, as well as novel genes associated with its onset

Current Research in Insect Science, 2022
Aedes albopictus and Aedes aegypti are mosquito species that are distributed worldwide and transmit diverse arboviruses of medical importance, such as those causing yellow fever, dengue, chikungunya and Zika. A.
Diego Felipe Araujo Diniz, Tatiany Patrícia Romão, Elisama Helvécio, Danilo de Carvalho-Leandro, Morgana do Nascimento Xavier, Christina Alves Peixoto, Osvaldo Pompílio de Melo Neto, Maria Alice Varjal de Melo-Santos, Constância Flávia Junqueira Ayres   +8 more
doaj   +1 more source

Fitness Costs Predict Emotional, Moral, and Attitudinal Inbreeding Aversion [PDF]

Frontiers in Psychology, 2016
In terms of sexual intercourse, the very last people we think about are our kin. Imagining inbreeding intercourse, whether it involves our closest kin or not, induces aversion in most people who invoke inbreeding depression problems or cultural considerations. Research has focused on the disgust felt when facing inbreeding intercourse between close kin
Lespiau, Florence, Kaminski, Gwenaël
openaire   +5 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source