Results 91 to 100 of about 577,400 (301)
Spatial Structure Mitigates Fitness Costs in Host-Parasite Coevolution [PDF]
The American Naturalist, 2014 The extent of population mixing is known to influence the coevolutionary outcomes of many host and parasite traits, including the evolution of generalism (the ability to resist or infect a broad range of genotypes). While the segregation of populations into interconnected demes has been shown to influence the evolution of generalism, the role of local ...
Ashby, Ben +2 more
openaire +5 more sources
Adaptive evolution of molecular phenotypes
, 2014 Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under
Armita Nourmohammad +13 more
core +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
In vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut
mSystemsThe widespread sulfonamide resistance genes sul1, sul2, and sul3 in food and gut bacteria have attracted considerable attention. In this study, we assessed the in vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli, using a murine ...
Han Jiang +6 more
doaj +1 more source
Integron in Gram negative bacteria: Classes and fitness cost
Asian Journal of Medical Sciences, 2017 Bacteria intrinsically harbor methods of gene exchange that are distinct from those in eukaryotes, but subject to natural selection laws. Dissemination of antimicrobial resistance is one of the major consequences of gene exchange ability.
Aisha M AlAmri
doaj +1 more source
Promoter Activity Buffering Reduces the Fitness Cost of Misregulation [PDF]
Cell Reports, 2017 Cells regulate gene expression by changing the concentration and activity of transcription factors (TFs). The response of each gene to changes in TF activity is generally assumed to be encoded in the promoter. Here we show that, even when the promoter itself remains constant, each gene has a unique TF dose response curve.
Schikora-Tamarit, Miquel Angel +6 more
openaire +4 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyIntroductionHeteroresistance is a well-known phenomenon contributing to treatment failure in bacterial infections. Previous research has traditionally linked it to genetic mechanisms, emphasizing fixed subpopulations with specific resistance mutations ...
YunTao Luo +6 more
doaj +1 more source
Males of the two-spotted spider mite attempt to copulate with mated females: effects of double mating on fitness of either sex [PDF]
In Tetranychus urticae (Acari: Tetranychidae), when the intervals between first and second copulation are more than 24 h, only the first copulation is effective for females.
Oku, K.
core +3 more sources
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source