Results 41 to 50 of about 2,688,225 (235)

Compensatory dynamics are rare in natural ecological communities [PDF]

, 2007
In population ecology, there has been a fundamental controversy about the relative importance of competition-driven (density-dependent) population regulation vs. abiotic influences such as temperature and precipitation.
Ernest, S.K. Morgan, McArdle, Brian H., Currie, D. J., Cumming, Graeme S., Houlahan, J. E., Magnuson, John J., Fuhlendorf, S. D., Russell, R., Wondzell, S. M., Muldavin, Esteban H., Cottenie, K., Russell, Robert, Magnuson, J. J., Legendre, P., Fuhlendorf, Samuel D., Stevens, R. D., Ernest, S. K. Morgan, Stevens, Richard D., Currie, David J., Ernest, S. K. M., Muldavin, E. H., Houlahan, Jeff E., Findlay, C. S., Magnusson, J. J., Gaedke, U., Willis, T. J., Cumming, G. S., Legendre, Pierre, Wondzell, Steve M., Woiwod, I. P., McArdle, B. H., Noble, David, Cummings, G. S., Woiwod, Ian P., Gaedke, Ursula (Prof. Dr.), Noble, D., Willis, Trevor J., Cottenie, Karl, Findlay, C. Scott   +38 more
core   +1 more source

Compensatory evolution on the adaptive landscape.

, 2014
Schematic representation of the impact of compensatory evolution on the fitness landscape. The x and y axes on the landscape locate the network of neighboring genotypic states, while the z axis defines fitness in a single environment.
Gábor Boross (621771), Frank C. P. Holstege (117137), Dorottya Kalapis (621772), Mónika Hrtyan (621775), Edit Rutkai (621776), Károly Kovács (263483), Balázs Papp (48589), Béla Szamecz (214737), Gergely Fekete (621773), Marian J. A. Groot Koerkamp (117136), Zoltán Farkas (621774), Patrick Kemmeren (492813), Viktória Lázár (4014650), Csaba Pál (4014644)   +13 more
core   +1 more source

Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation.

PLoS Biology, 2021
Plasmids play an important role in bacterial genome evolution by transferring genes between lineages. Fitness costs associated with plasmid carriage are expected to be a barrier to gene exchange, but the causes of plasmid fitness costs are poorly ...
James P J Hall, Rosanna C T Wright, Ellie Harrison, Katie J Muddiman, A Jamie Wood, Steve Paterson, Michael A Brockhurst   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Compensatory mutation can drive gene regulatory network evolution

, 2020
Gene regulatory networks underlie every aspect of life; better understanding their assembly would better our understanding of evolution more generally.
Wang, Yifei, Priest, Nicholas, Richards, Marios, Bryson, Joanna, Dorus, Steve   +4 more
core   +1 more source

Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components

BMC Genomics, 2009
Background The deleterious effect of a mutation can be reverted by a second-site interacting residue. This is an epistatic compensatory process explaining why mutations that are deleterious in some species are tolerated in phylogenetically related ...
Moleirinho Ana, van Asch Barbara, Carneiro João, Azevedo Luísa, Pereira Filipe, Amorim António   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Parallel Compensatory Evolution Stabilizes Plasmids across the Parasitism-Mutualism Continuum [PDF]

, 2015
Plasmids drive genomic diversity in bacteria via horizontal gene transfer [1, 2]; nevertheless, explaining their survival in bacterial populations is challenging [3]. Theory predicts that irrespective of their net fitness effects, plasmids should be lost:
Paterson, S., Guymer, D., Brockhurst, Michael A.; id_orcid, Spiers, Andrew J, Spiers, Andrew J.; id_orcid, Brockhurst, M.A., Spiers, Andrew J., Spiers, A.J., Harrison, Ellie, Guymer, David, Brockhurst, Michael A., Paterson, Steve, Brockhurst, Michael A, Harrison, E.   +13 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source