Results 1 to 10 of about 5,764,173 (258)
Genetic interactions reveal the evolutionary trajectories of duplicate genes
Molecular Systems Biology, 2010 The characterization of functional redundancy and divergence between duplicate genes is an important step in understanding the evolution of genetic systems.
Benjamin VanderSluis +9 more
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From E‐MAPs to module maps: dissecting quantitative genetic interactions using physical interactions
Molecular Systems Biology, 2008 Recent technological breakthroughs allow the quantification of hundreds of thousands of genetic interactions (GIs) in Saccharomyces cerevisiae. The interpretation of these data is often difficult, but it can be improved by the joint analysis of GIs along
Igor Ulitsky +3 more
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Influence of Genetic Interactions on Polygenic Prediction
G3: Genes, Genomes, Genetics, 2020 Prediction of phenotypes from genotypes is an important objective to fulfill the promises of genomics, precision medicine and agriculture. Although it’s now possible to account for the majority of genetic variation through model fitting, prediction of ...
Zhijun Dai, Nanye Long, Wen Huang
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Toward an integrated map of genetic interactions in cancer cells
Molecular Systems Biology, 2018 Cancer genomes often harbor hundreds of molecular aberrations. Such genetic variants can be drivers or passengers of tumorigenesis and create vulnerabilities for potential therapeutic exploitation.
Benedikt Rauscher +5 more
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Differential genetic interactions of yeast stress response MAPK pathways
Molecular Systems Biology, 2015 Genetic interaction screens have been applied with great success in several organisms to study gene function and the genetic architecture of the cell. However, most studies have been performed under optimal growth conditions even though many functional ...
Humberto Martin +9 more
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Cancer Biology & Medicine, 2022 Objective: Effective adjuvant therapeutic strategies are urgently needed to overcome MAPK inhibitor (MAPKi) resistance, which is one of the most common forms of resistance that has emerged in many types of cancers.
Yu Yu +14 more
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A comparative analysis of telomere length maintenance circuits in fission and budding yeast
Frontiers in Genetics, 2022 The natural ends of the linear eukaryotic chromosomes are protected by telomeres, which also play an important role in aging and cancer development. Telomere length varies between species, but it is strictly controlled in all organisms.
Iftah Peretz +2 more
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Microbiome, 2020 An amendment to this paper has been published and can be accessed via the original article.
Kyle Hartman +5 more
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Frontiers in Aging Neuroscience, 2022 Mice expressing human amyloid precursor protein (APP) containing the dominant Swedish and Iberian mutations (AppNL–F) or also Arctic mutation (AppNL–G–F) show neuropathology and hippocampus-dependent cognitive impairments pertinent to Alzheimer’s disease
Sarah Holden +12 more
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Natural variants suppress mutations in hundreds of essential genes
Molecular Systems Biology, 2021 The consequence of a mutation can be influenced by the context in which it operates. For example, loss of gene function may be tolerated in one genetic background, and lethal in another.
Leopold Parts +11 more
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