Results 41 to 50 of about 5,764,173 (258)

Genetic interactions during root hair morphogenesis in Arabidopsis. [PDF]

, 2000
Root hairs are a major site for the uptake of water and nutrients into plants and form an increasingly important model system for studies of development of higher plants and cell biology.
Parker, JS, Alison C. Cavell, Claire S. Grierson, Jill S. Parker, Keith Roberts, Parker, J. S., Roberts, K., Cavell, A. C., Grierson, CS, Grierson, C. S., Liam Dolan, Dolan, L, Dolan, Liam, Cavell, AC, Roberts, K, Dolan, L.   +15 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Common Genetic Variation and the Control of HIV-1 in Humans [PDF]

, 2009
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects.
Cirulli, Elizabeth T, Gunthard, HF, Thomas J. Urban, Andrew J. Mcmichael, Guenthard, Huldrych F., Gumbs, CE, Feng, S, Feng, Sheng, De Luca Andrea, McMichael, A. J, Obel, N., Miró Meda, José M. (José María), 1956-, O'Brien SJ, Haynes BF, Haynes, B. F, Ge, D., Letvin, Norman L., Jeremy J. Martinson, Martinson, J. J, Beckmann, J S, Smith, Jason P., Descombes P, Cozzi-Lepri, A, Jacobson, L P, Margolick, J B, Cirulli, E. T, Shianna, K V, Niels Obel, Ge Dongliang, Simon Mallal, Wolinsky, Steven M, Jacques S Beckmann, Urban TJ, O'Brien, S J, Antonarakis, S.E., Wolinsky, S. M, Bruno Ledergerber, Telenti, A., Urban, T.J., Ge, DL, Detels, R, Javier Martinez-Picado, Günthard, H F, Letvin, NL, Jason P. Smith, Zhang, Kunlin, Cirulli Elizabeth T., Colombo S, Colombo, S, McMichael, AJ, Feng S, McMichael, Andrew J., Joseph B. Margolick, Mussini, C., Cozzi-Lepri Alessandro, Sheng Feng, Descombes Patrick, Letvin NL, Goldstein, DB, Barton F. Haynes, Fellay, J., Jacobson, Lisa, Goldstein, D. B., Feng, S., Martínez Picado, Francisco Javier, Antonella Castagna, Haynes, BF, Telenti, A, Jacobson, L.P., Shianna, K.V., Fellay Jacques, Miro, José M, Antonarakis Stylianos E., Mcmichael, Andrew, David B Goldstein, Gumbs, C. E, Jacobson, Lisa P., Miro, José M., Jason P Smith, Miro, J.M., Cirulli, Elizabeth T., Antonarakis SE, Shianna, Kevin V, Easterbrook, P, Martinson, Jeremy J, Stylianos E Antonarakis, Gumbs, Curtis E, O'Brien, Stephen J, Mary Carrington, Mallal, S, Zhang, K, Curtis E. Gumbs, Castagna, A., Martinson, J J, Detels, Roger, Wolinsky SM, Easterbrook, Philippa, Haynes, Barton F, Letvin, N L, Letvin, N. L, Colombo, Sara, Martinez Picado J, Gumbs CE, Cozzi Lepri A, Haynes, B F, Smith, J P, Letvin, Norman L, Jacques Fellay, Ledergerber B, Telenti, Amalio, Carrington M, Dalmau, J., Mallal, Simon, De Luca, Andrea, Easterbrook Philippa, Martinez-Picado Javier, Wolinsky, Steven, Dalmau J, Beckmann, Jacques, Jacobson, L. P, O'Brien, S. J, Margolick, Joseph B, NIAID Center for HIV/AIDS Vaccine Immunology, Amalio Telenti* David B. Goldstein, Miro, J. M, Dongliang Ge, Margolick JB, Shianna, K. V, Cozzi-Lepri, Alessandro, Smith, J. P., Elizabeth T Cirulli, Amalio Telenti, Jacobson Lisa P., Carrington Mary, Goldstein, David B, Huldrych F. Günthard, Gumbs Curtis E., De, Luca A., Feng Sheng, Urban, TJ, Carrington, M, Antonarakis, Stylianos E, Kevin V Shianna, Ledergerber, B., Martinson Jeremy J., Martinson, Jeremy J., Goldstein, David B., Urban, T J, Urban Thomas J., Günthard, H. F, Margolick Joseph B., Cristina Mussini, Elizabeth T, Ge, Dongliang, Urban, Thomas J., Stylianos E. Antonarakis, Günthard, H.F., McMichael AJ, Wolinsky Steven M., Telenti Amalio, Martinez-Picado, J, Miro, J M, Cirulli ET, Huldrych F Günthard, Urban, Thomas J, Stephen J O'Brien, Martinez-Picado, Javier, Steven M. Wolinsky, Zhang K, Easterbrook P, Cirulli, Elisabeth T., Curtis E Gumbs, José M Miro, Shianna Kevin V., Jacobson, Lisa P, Wolinsky, S M, Lisa P. Jacobson, Günthard HF, Martinson, J.J., Norman L Letvin, Mallal Simon, Ledergerber, B, McMichael, A.J., McMichael, Andrew J, Smith, J.P., Gumbs, Curtis E., Günthard, Huldrych F., Smith, JP, Fellay, Jacques, Beckmann, Jacques S., Antonarakis, SE, Miro JM, Ledergerber, Bruno, Telenti A, Lisa P Jacobson, Wolinsky, Steven M., Roger Detels, Antonarakis, S E, Urban, T. J, Mallal, S., Günthard, Huldrych F, Obel, N, Cirulli, E T, Martinson JJ, Patrick Descombes, Ledergerber Bruno, Haynes Barton F., Mussini, C, Philippa Easterbrook, Descombes, P, Fellay J, Goldstein David B., Fellay, J, Margolick, Joseph B., Goldstein, D B, Steven M Wolinsky, Zhang Kunlin, Castagna A, Smith, Jason P, Descombes, Patrick, Gumbs, C E, Letvin Norman L., Goldstein, D.B., Margolick, JB, Smith JP, Smith, J. P, Beckmann, J. S, Wolinsky, S.M., Beckmann, Jacques S, Andrew J McMichael, Andrea De Luca, Beckmann, J.S., Jeremy J Martinson, Beckmann JS, NIAID Ctr HIV AIDS Vaccine Immunol, Shianna, KV, Haynes, Barton F., Gumbs, C.E., Jacques S. Beckmann, Ge D, McCarthy, M.I., Ge, D, McMichael Andrew J., Cirulli, ET, O'Brien, Stephen J., Norman L. Letvin, O\u27Brien, Stephen J., Dalmau Judith, Cozzi-Lepri, A., Haynes, B.F., Detels R, Ro Cozzi-lepri, Smith Jason P., Margolick, J.B., Günthard Huldrych F., Gumbs, Curtis, Zhang, KL, Colombo, S., Margolick, Joseph, De Luca A, Margolick, J. B, Beckmann Jacques S., O'Brien, Stephen, Shianna, Kevin V., Barton F Haynes, Dalmau, J, Kevin V. Shianna, Jacobson, LP, Wolinsky, SM, Martinez-Picado, J., Antonarakis, S. E, Mallal S, Carrington, Mary, Colombo Sara, Zhang, K., Letvin, N.L., Castagna, A, Obel, Niels, Mussini, Cristina, Detels Roger, O'Brien, S.J., Carrington, M., Obel Niels, Cirulli, E.T., Antonarakis, Stylianos E., Goldstein DB, Thomas J Urban, Descombes, P., Castagna, Antonella, Jose ́ M. Miro, Miro, JM, Sara Colombo, Judith Dalmau, O'Brien Stephen J., De Luca, A., Kunlin Zhang, Castagna Antonella, De Luca, A, Beckmann, JS, Stephen J. O’brien, Mussini Cristina, Easterbrook, P., Jacobson LP, Miro José M., Martinson, JJ, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI), Obel N, O'Brien, SJ, Shianna KV, Dalmau, Judith, McMichael, A J, Letvin, Norman Lee, Joseph B Margolick, Detels, R., Alessandro Cozzi-Lepri, CASTAGNA , ANTONELLA, Guenthard Huldrych F., Miró Meda, José M., Cozzi Lepri Alessandro, Martinez Picado Javier   +319 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Leveraging synthetic genetic array screening to identify therapeutic targets and inhibitors for combatting azole resistance in Candida glabrata

Microbiology Spectrum
Fungal infections affect over 6.55 million individuals annually, with Candida glabrata (recently reclassified as Nakaseomyces glabratus) being the second most common cause of invasive candidiasis and candidemia, conditions that carry a high mortality ...
Catrin C. Williams, Jane Usher
doaj   +1 more source

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping

Cell Reports, 2017
A comprehensive view of molecular chaperone function in the cell was obtained through a systematic global integrative network approach based on physical (protein-protein) and genetic (gene-gene or epistatic) interaction mapping.
Kamran Rizzolo, Jennifer Huen, Ashwani Kumar, Sadhna Phanse, James Vlasblom, Yoshito Kakihara, Hussein A. Zeineddine, Zoran Minic, Jamie Snider, Wen Wang, Carles Pons, Thiago V. Seraphim, Edgar Erik Boczek, Simon Alberti, Michael Costanzo, Chad L. Myers, Igor Stagljar, Charles Boone, Mohan Babu, Walid A. Houry   +19 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Genetic variation of metabolite and hormone concentration in UK Holstein-Friesian calves and the genetic relationship with economically important traits [PDF]

, 2009
The decline of dairy cattle fertility worldwide remains a major concern, with conception rates to first service commonly below 40%. The length and severity of negative energy balance postpartum are unfavorably correlated with fertility, suggesting that ...
Woolliams, J A, Royal, M D, Flint, A P F, Hayhurst, C, Løvendahl, P   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source