Results 11 to 20 of about 5,764,173 (258)

Detecting genetic interactions with visible neural networks. [PDF]

Commun Biol
Non-linear interactions among single nucleotide polymorphisms (SNPs), genes, and pathways play an important role in human diseases, but identifying these interactions is a challenging task.
van Hilten A, Melograna F, Fan B, Niessen W, van Steen K, Roshchupkin G.   +5 more
europepmc   +3 more sources

The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth [PDF]

eLife
Genetic analyses, which examine the phenotypic effects of mutations both individually and in combination, have been fundamental to our understanding of cellular functions.
Lucas Fuentes Valenzuela, Paul Francois, Jan M Skotheim   +2 more
doaj   +2 more sources

Imputation of quantitative genetic interactions in epistatic MAPs by interaction propagation matrix completion [PDF]

, 2014
A popular large-scale gene interaction discovery platform is the Epistatic Miniarray Profile (E-MAP). E-MAPs benefit from quantitative output, which makes it possible to detect subtle interactions.
Marinka Žitnik, Zupan, Blaz, Blaž Zupan, Zitnik, Marinka   +3 more
core   +2 more sources

Nicotiana benthamiana is a suitable transient system for high-level expression of an active inhibitor of cotton boll weevil α-amylase

BMC Biotechnology, 2019
Background Insect resistance in crops represents a main challenge for agriculture. Transgenic approaches based on proteins displaying insect resistance properties are widely used as efficient breeding strategies.
Guilherme Souza Prado, Pingdwende Kader Aziz Bamogo, Joel Antônio Cordeiro de Abreu, François-Xavier Gillet, Vanessa Olinto dos Santos, Maria Cristina Mattar Silva, Jean-Paul Brizard, Marcelo Porto Bemquerer, Martine Bangratz, Christophe Brugidou, Drissa Sérémé, Maria Fatima Grossi-de-Sa, Séverine Lacombe   +12 more
doaj   +1 more source

Concepts and considerations for enhancing RNAi efficiency in phytopathogenic fungi for RNAi-based crop protection using nanocarrier-mediated dsRNA delivery systems

Frontiers in Fungal Biology, 2022
Existing, emerging, and reemerging strains of phytopathogenic fungi pose a significant threat to agricultural productivity globally. This risk is further exacerbated by the lack of resistance source(s) in plants or a breakdown of resistance by pathogens ...
Poonam Ray, Debashish Sahu, Raghavendra Aminedi, Divya Chandran   +3 more
doaj   +1 more source

Correction to: Cropping practices manipulate abundance patterns of root and soil microbiome members paving the way to smart farming

Microbiome, 2018
Following publication of the original article [1], the authors reported that while the ordination graphs are all correct, the symbols in the legend are wrong.
Kyle Hartman, Marcel G. A. van der Heijden, Raphaël A. Wittwer, Samiran Banerjee, Jean-Claude Walser, Klaus Schlaeppi   +5 more
doaj   +1 more source

Cropping practices manipulate abundance patterns of root and soil microbiome members paving the way to smart farming

Microbiome, 2018
Background Harnessing beneficial microbes presents a promising strategy to optimize plant growth and agricultural sustainability. Little is known to which extent and how specifically soil and plant microbiomes can be manipulated through different ...
Kyle Hartman, Marcel G. A. van der Heijden, Raphaël A. Wittwer, Samiran Banerjee, Jean-Claude Walser, Klaus Schlaeppi   +5 more
doaj   +1 more source

Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain

eLife, 2021
Vascular endothelial cells (vECs) in the brain exhibit structural and functional heterogeneity. Fenestrated, permeable brain vasculature mediates neuroendocrine function, body-fluid regulation, and neural immune responses; however, its vascular formation
Sweta Parab, Rachael E Quick, Ryota L Matsuoka   +2 more
doaj   +1 more source

Time-resolved mapping of genetic interactions to model rewiring of signaling pathways

eLife, 2018
Context-dependent changes in genetic interactions are an important feature of cellular pathways and their varying responses under different environmental conditions.
Florian Heigwer, Christian Scheeder, Thilo Miersch, Barbara Schmitt, Claudia Blass, Mischan Vali Pour Jamnani, Michael Boutros   +6 more
doaj   +1 more source

Emergence and propagation of epistasis in metabolic networks

eLife, 2021
Epistasis is often used to probe functional relationships between genes, and it plays an important role in evolution. However, we lack theory to understand how functional relationships at the molecular level translate into epistasis at the level of whole-
Sergey Kryazhimskiy
doaj   +1 more source