Results 31 to 40 of about 2,688,225 (235)
mSystems, 2022 Understanding the fitness costs associated with plasmid carriage is a key to better understanding the mechanisms of plasmid maintenance in bacteria. In the current work, we performed multiple serial passages (63 days, 627.8 generations) to identify the ...
Jin-Fei Zhang +10 more
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BMC Ecology and Evolution, 2021 Background The impact of genetic interaction networks on evolution is a fundamental issue. Previous studies have demonstrated that the topology of the network is determined by the properties of the cellular machinery.
Joanna Klim +5 more
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Molecular phylogenetic evaluation of classification and scenarios of character evolution in calcareous sponges (Porifera, Class Calcarea). [PDF]
, 2012 Calcareous sponges (Phylum Porifera, Class Calcarea) are known to be taxonomically difficult. Previous molecular studies have revealed many discrepancies between classically recognized taxa and the observed relationships at the order, family and genus ...
Oliver Voigt (90080) +11 more
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Systematic analysis of bypass suppression of essential genes
Molecular Systems Biology, 2020 Essential genes tend to be highly conserved across eukaryotes, but, in some cases, their critical roles can be bypassed through genetic rewiring. From a systematic analysis of 728 different essential yeast genes, we discovered that 124 (17%) were ...
Jolanda van Leeuwen +18 more
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Heliyon, 2021 The liver is a key organ that performs diverse functions such as metabolic processing of nutrients or disposal of dangerous substances (xenobiotics). Accordingly, it seems to be protected by several mechanisms throughout the life of organisms, one of ...
Blanca Delgado-Coello
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Frontiers in Microbiology, 2021 Bacteriophage T7 gene 17.5 coding for the only known holin is one of the components of its lysis system, but the holin activity in T7 is more complex than a single gene, and evidence points to the existence of additional T7 genes with holin activity.
Hai Xu +12 more
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Empirical approaches to detecting the action of natural selection in Drosophila [PDF]
, 2004 This dissertation examines two aspects of how natural selection shapes the amount and pattern of genetic variation within and between species: (1) the role of positively selected alleles in shaping the variation within and between subpopulations of a ...
Baines, John
core +1 more source
Rapid protein sequence evolution via compensatory frameshift is widespread in RNA virus genomes
BMC Bioinformatics, 2021 Background RNA viruses possess remarkable evolutionary versatility driven by the high mutability of their genomes. Frameshifting nucleotide insertions or deletions (indels), which cause the premature termination of proteins, are frequently observed in ...
Dongbin Park, Yoonsoo Hahn
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eLife, 2019 Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of ...
Anett Dunai +12 more
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Coevolution within and between regulatory loci can preserve promoter function despite evolutionary rate acceleration. [PDF]
PLoS Genetics, 2012 Phenotypes that appear to be conserved could be maintained not only by strong purifying selection on the underlying genetic systems, but also by stabilizing selection acting via compensatory mutations with balanced effects.
Antoine Barrière +2 more
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