Results 191 to 200 of about 880,593 (358)

lncRNAs: a new generation of targets and biomarkers in thyroid cancer. [PDF]

Eur Thyroid J
Maturi R, Esposito M, Coppes RP, De Vita G.   +3 more
europepmc   +1 more source

TheFragaria vescaHomolog of SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 Represses Flowering and Promotes Vegetative Growth [PDF]

, 2013
Katriina Mouhu, Takeshi Kurokura, Elli Koskela, Victor A. Albert, Paula Elomaa, Timo Hytönen   +5 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Suppressor

Seibutsu Butsuri, 1966
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

EML4-ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis. [PDF]

Cancer Discov
Diaz-Jimenez A, Shuldiner EG, Somogyi K, Shih KY, González-Velasco Ó, Najajreh M, Kim S, Akkas F, Murray CW, Andrejka L, Tsai MK, Brors B, Hofmann I, Sivakumar S, Sisoudiya SD, Sokol ES, Cai H, Petrov DA, Winslow MM, Sotillo R.   +19 more
europepmc   +1 more source

Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway

, 2013
Xiaodong Ma, Saibyasachi N. Choudhury, Hua Xiang, Zhongping Dai, Yong Li   +4 more
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Retraction: MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277 [PDF]

, 2002
Jiri Buzek
openalex   +1 more source