Results 291 to 300 of about 880,593 (358)

Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 Complexes. [PDF]

Cancer Discov
Tang YJ, Xu H, Hughes NW, Ruiz P, Kim SH, Shuldiner EG, Lopez SS, Hebert JD, Karmakar S, Andrejka L, Dolcen DN, Boross G, Chu P, Kunder CA, Detrick C, Pierce SE, Ashkin EL, Greenleaf WJ, Voss AK, Thomas T, van de Rijn M, Petrov DA, Winslow MM.   +22 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

A Review of ARID1A's Role in Breast Cancer Progression: Context-Dependent Mechanisms and Therapeutic Implications. [PDF]

Cancers (Basel)
Shankari G, Prabhu D, Sureshan M, Jeyakanthan J, Rajamanikandan S.   +4 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Epigenetic regulation of the tumor microenvironment in lung cancer: mechanism insights and therapeutic prospects. [PDF]

Front Immunol
Yang M, Lei X, Ren D, Qin D, Xia X.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer. [PDF]

Int J Mol Med
Qiao G, Li J, Wang J, Wang Z, Bian W.
europepmc   +1 more source

Functional Characterization of Suppressor of Cytokine Signalling 6 and Its Interaction with Erythropoietin Receptor in Colorectal Cancer Cells. [PDF]

Cancers (Basel)
Al-Bahri A, Zadjali F, Hanif S, Alharthi Z, Sakr H, Al-Kharusi A.   +5 more
europepmc   +1 more source

Intragenic suppressors of the <i>C. elegans</i> <i>clk-2(qm37)</i> mutation. [PDF]

MicroPubl Biol
Pascal M, Cappadocia L, Hekimi S, Bénard CY.   +3 more
europepmc   +1 more source

Loss of <i>CDKN2A/B</i> is a Hallmark of RTK II Glioblastomas. [PDF]

J Cancer
Langwieder CK, Hölzl D, Hutarew G, Schlicker HU, Alinger-Scharinger B, Schwartz C, Sotlar K, Kraus TFJ.   +7 more
europepmc   +1 more source