Results 71 to 80 of about 641,238 (306)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Analysis of Pineapple Mealybug Wilt Associated Virus -1 and -2 for Potential RNA Silencing Suppressors and Pathogenicity Factors

Viruses, 2015
Higher plants use RNA silencing to defend against viral infections. As a counter defense, plant viruses have evolved proteins that suppress RNA silencing.
Kishore K. Dey, Wayne B. Borth, Michael J. Melzer, Ming-Li Wang, John S. Hu   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Directed Experimental Adaptive Evolution of Osmoregulation in Fungal Pathogen Magnaporthe oryzae Is Independent of Glycerol Metabolism-Associated Genes

Biology
Directed experimental adaptive evolution in fungal pathogens is largely unexplored. In the phytopathogenic fungus Magnaporthe oryzae, long-term cultivation under osmotic stress was found to lead to individuals arising as suppressor strains out of ...
Katharina Bersching, Christiane Grünewald, Stefan Jacob   +2 more
doaj   +1 more source

Suppressor cell induction in vitro. I. Kinetics of induction of antigen-specific suppressor cells.

, 1976
The induction of antigen-specific suppressor cells in vitro, using high concentrations (100 mug/ml) of keyhole limpet hemocyanin (KLH) in Marbrook flasks is described.
Kontiainen, S, Sirkka Kontiainen, Feldmann, M, Marc Feldmann   +3 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Double-Edged Sword of Tumour Suppressor Genes in Schizophrenia

Frontiers in Molecular Neuroscience, 2019
Schizophrenia (SCZ) is a common psychiatric disorder with polygenetic pathogenesis. Among the many identified candidate genes and loci, the group of tumour suppressor genes has drawn our interest.
Chuanjun Zhuo, Chuanjun Zhuo, Chuanjun Zhuo, Chuanjun Zhuo, Dawei Wang, Chunhua Zhou, Ce Chen, Jie Li, Hongjun Tian, Shen Li, Shen Li, Feng Ji, Chuanxin Liu, Min Chen, Li Zhang   +14 more
doaj   +1 more source

The oncogene and tumour suppressor gene factsbook /

, 1997
The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour ...
Hesketh, Robin.
core  

Parametric analysis of the suppressor. [PDF]

, 2019
The topic of Master thesis is research of sound suppressor of rifle. In thesis are compared results of performed field tests of rifle shoots with and without sound suppressor.
Radžius, Tomas,
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source