Results 11 to 20 of about 3,703 (215)

Supramolecular Frameworks Based on Rhenium Clusters Using the Synthons Approach [PDF]

Molecules, 2021
The reaction of the K4[{Re6Si8}(OH)a6]·8H2O rhenium cluster salt with pyrazine (Pz) in aqueous solutions of alkaline or alkaline earth salts at 4 °C or at room temperature leads to apical ligand exchange and to the formation of five new compounds: [trans-
Nathalie Audebrand, Antoine Demont, Racha El Osta, Yuri V. Mironov, Nikolay G. Naumov, Stéphane Cordier   +5 more
doaj   +4 more sources

Supramolecular Synthon Promiscuity in Phosphoric Acid-Dihydrogen Phosphate Ionic Cocrystals. [PDF]

Cryst Growth Des, 2022
Approximately 80% of active pharmaceutical ingredients (APIs) studied as lead candidates in drug development exhibit low aqueous solubility, which typically results in such APIs being poorly absorbed and exhibiting low bioavailability. Salts of ionizable APIs and, more recently, pharmaceutical cocrystals can address low solubility and other relevant ...
Haskins MM, Lusi M, Zaworotko MJ.
europepmc   +3 more sources

Modular protein frameworks via supramolecular synthons. [PDF]

Biophys Rev
Abstract Controlled protein assembly and protein crystal engineering are routes to new types of biomaterials. In this review, we examine how crystal engineering concepts, including polymorph searching, molecular tectonics and supramolecular synthons, can be adapted and applied in protein-based systems.
Mockler NM, Crowley PB.
europepmc   +2 more sources

Making and Breaking Supramolecular Synthons for Modular Protein Frameworks. [PDF]

Chemistry
AbstractAnionic calixarenes are useful mediators of protein assembly. In some cases, protein – calixarene cocrystallization yields multiple polymorphs. Ralstonia solanacearum lectin (RSL) cocrystallizes with p‐sulfonato‐calix[8]arene (sclx8) in at least four distinct pH‐dependent arrangements.
Mockler NM, Raston CL, Crowley PB.
europepmc   +3 more sources

Double Salts and Racemate in Mefloquine–Ibuprofen and Mefloquine–Ketoprofen Systems. A Structural and Thermochemical Analysis [PDF]

Chirality
(S)‐ibuprofen or ketoprofen were used to resolve mefloquine, forming double salts structurally similar to the racemic forms. ABSTRACT The formation of salts remains a highly sought‐after yet unpredictable strategy for resolving chiral drugs. Using a drug–drug approach, we have investigated the crystallization behavior of Mefloquine (Mf), a racemic ...
Martins J, Segatto J, Tenorio J, Carvalho P.   +3 more
europepmc   +2 more sources

Supramolecular Synthons in Protein-Ligand Frameworks. [PDF]

Cryst Growth Des
Supramolecular synthons, defined as reproducible intermolecular structural units, have greatly aided small molecule crystal engineering. In this paper, we propose that supramolecular synthons guide ligand-mediated protein crystallization. The protein RSL and the macrocycle sulfonato-calix[8]arene cocrystallize in at least four ways.
Flood RJ, Mockler NM, Thureau A, Malinska M, Crowley PB.   +4 more
europepmc   +3 more sources

Real-Time In Situ Imaging of Aggregation-Induced Emission and Solvent-Guided Morphogenesis of a "V-Shaped" 4-Amino-1,8-Naphthalimide Tröger's Base Supramolecular Scaffold. [PDF]

Small Sci
It is demonstrated that the self‐assembly process of the 3‐pyridyl‐based TBNap structure is highly solvent deepened. X‐ray diffraction analysis confirms that the TBNap structure possesses solvent‐depended packing arrangements in the crystalized form.
Shanmugaraju S, Umadevi D, Savyasachi AJ, Hawes CS, Kitchen JA, McManus GJ, Gunnlaugsson T.   +6 more
europepmc   +2 more sources

Crystal landscape in the orcinol:4,4′-bipyridine system: synthon modularity, polymorphism and transferability of multipole charge density parameters

IUCrJ, 2014
Polymorphism in the orcinol:4,4′-bipyridine cocrystal system is analyzed in terms of a robust convergent modular phenol...pyridine supramolecular synthon.
Ritesh Dubey, Mysore S. Pavan, Tayur N. Guru Row, Gautam R Desiraju   +3 more
doaj   +1 more source

Hydrogen-bonding landscape of the carbamoylcyanonitrosomethanide anion in the crystal structure of its ammonium salt

Acta Crystallographica Section E: Crystallographic Communications, 2021
The structure of the title salt, ammonium carbamoylcyanonitrosomethanide, NH4+·C3H2N3O2−, features the co-existence of different hydrogen-bonding patterns, which are specific to each of the three functional groups (nitroso, carbamoyl and cyano) of the ...
Kostiantyn V. Domasevitch, Ganna A. Senchyk, Andrey B. Lysenko, Eduard B. Rusanov   +3 more
doaj   +1 more source

Carbamazepine on a carbamazepine monolayer forms unique 1D supramolecular assemblies [PDF]

, 2011
High-resolution STM imaging of the structures formed by carbamazepine molecules adsorbed onto a pseudo-ordered carbamazepine monolayer on Au(111) shows the formation of previously unreported 1-dimensional supramolecular ...
Florence, Alastair J, Iski, Erin V., Johnston, Blair F, Sykes, E. Charles H., Urquhart, Andrew J   +4 more
core   +1 more source