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PET-CT imaging in a patient with progressive supranuclear palsy [PDF]
, 2015 Hosp Beneficencia Portuguesa São Paulo, Med Imagem, BR-01323001 São Paulo, SP, BrazilUniversidade Federal de São Paulo, Dept Neurol, São Paulo, SP, BrazilHosp Coracao, São Paulo, SP, BrazilUniversidade Federal de São Paulo, Dept Neurol, São Paulo, SP ...Amaral, Lazaro Luiz Faria do, Barsottini, Orlando G., Belezia, Anderson Benine, Marussi, Victor Hugo Rocha, Oliveira, Acary Souza Bulle, Pedroso, Jose Luiz, Yared, James +6 morecore +2 more sourcesBrain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy
Movement Disorders, EarlyView.Abstract Background
Clinical progression rate is the typical primary endpoint measure in progressive supranuclear palsy (PSP) clinical trials. Objectives
This longitudinal multicohort study investigated whether baseline clinical severity and regional brain atrophy could predict clinical progression in PSP–Richardson's syndrome (PSP‐RS).Andrea Quattrone, Nicolai Franzmeier, Hans‐Jürgen Huppertz, Nicholas Seneca, Gabor C. Petzold, Annika Spottke, Johannes Levin, Johannes Prudlo, Emrah Düzel, the PASSPORT Study Group, the AL‐108‐231 Investigators, the Arise Investigators, the Tauros MRI Investigators, the DESCRIBE‐PSP group, Ikuko Aiba, Angelo Antonini, Diana Apetauerova, Jean‐Philippe Azulay, Ernest Balaguer Martinez, Jee Bang, Paolo Barone, Matthew Barrett, Danny Bega, Daniela Berg, Koldo Berganzo Corrales, Yvette Bordelon, Adam L Boxer, Moritz Brandt, Norbert Brueggemann, Giovanni Castelnovo, Roberto Ceravolo, Rosalind Chuang, Sun Ju Chung, Alistair Church, Jean‐Christophe Corvol, Paola Cudia, Marian Dale, Luc Defebvre, Sophie Drapier, Erika D Driver‐Dunckley, Georg Ebersbach, Karla M Eggert, Aaron Ellenbogen, Alexandre Eusebio, Andrew H Evans, Natalia Fedorova, Elizabeth Finger, Alexandra Foubert‐Samier, Boyd Ghosh, Lawrence Golbe, Francisco Grandas Perez, Murray Grossman, Deborah Hall, Kyoko Hamada, Kazuko Hasegawa, Guenter Hoeglinger, Lawrence Honig, David Houghton, Xuemei Huang, Stuart Isaacson, Seong‐Beom Koh, Jaime Kulisevsky Bojarski, Anthony E. Lang, Peter Nigel Leigh, Irene Litvan, Juan Jose Lopez Lozano, Jose Luis Lopez‐Sendon Moreno, Albert Christian Ludolph, Ma Rosario Luquin Piudo, Irene Martinez Torres, Nikolaus McFarland, Wassilios Meissner, Tiago Mestre, Pablo Mir Rivera, Eric Molho, Britt Mollenhauer, Huw R Morris, Miho Murata, Tomokazu Obi, Fabienne Ory Magne, Padraig O'Suilleabhain, Rajesh Pahwa, Alexander Pantelyat, Nicola Pavese, Dmitry Pokhabov, Johannes Prudlo, Federico Rodriguez‐Porcel, James Rowe, Joseph Savitt, Alfons Schnitzler, Joerg B Schulz, Klaus Seppi, Binit Shah, Holly Shill, David Shprecher, Maria Stamelou, Malcolm Steiger, Yuji Takahashi, Hiroshi Takigawa, Carmela Tartaglia, Lars Toenges, Daniel Truong, Winona Tse, Paul Tuite, Dieter Volc, Anne‐Marie A Wills, Dirk Woitalla, Tao Xie, Tatsuhiko Yuasa, Sarah Elizabeth Zauber, Theresa Zesiewicz, David Williams, Anne Louise Lafontaine, Connie Marras, Mandar Jog, Michael Panisset, Anthony Lang, Lesley Parker, Alistair J. Stewart, Jean‐Christophe Corvol, Jean‐Philippe Azulay, Philippe Couratier, Brit Mollenhauer, Stefan Lorenzl, Albert Ludolph, Reiner Benecke, Günter Höglinger, Axel Lipp, Heinz Reichmann, Dirk Woitalla, Dennis Chan, Adam Zermansky, David Burn, Andrew Lees, Adam Boxer, Bruce L. Miller, Iryna V. Lobach, Erik Roberson, Lawrence Honig, Edward Zamrini, Rajesh Pahwa, Yvette Bor‐delon, Erika Driver‐Dunkley, Stephanie Lessig, Mark Lew, Kyle Womack, Brad Boeve, Joseph Ferrara, Argyle Hillis, Daniel Kaufer, Rajeev Kumar, Tao Xie, Steven Gunzler, Theresa Zesiewicz, Praveen Dayalu, Lawrence Golbe, Murray Grossman, Joseph Jancovic, Scott McGinnis, Anthony Santiago, Paul Tuite, Stuart Isaacson, Julie Leegwater‐Kim, Irene Litvan, Murray Grossman, David S. Knopman, Bruce L. Miller, Lon S. Schneider, Rachelle S. Doody, Lawrence I. Golbe, Erik D. Roberson, Mary Koestler, Clifford R. Jack, Viviana Van Deerlin, Christopher Randolph, Iryna V. Lobach, Illana Gozes, Steve Whitaker, Joe Hirman, Michael Gold, Bruce H. Morimoto, Anwar Ahmed, Ikuko Aiba, Alberto Albanese, Kelly Bertram, Yvette Bordelon, James Bower, Jared Brosch, Daniel Claassen, Carlo Colosimo, Jean‐Christophe Corvol, Paola Cudia, Antonio Daniele, Luc Defebvre, Erika Driver‐Dunckley, Antoine Duquette, Roberto Eleopra, Alexandre Eusebio, Victor Fung, David Geldmacher, Lawrence Golbe, Francisco Grandas, Deborah Hall, Taku Hatano, Günter U Höglinger, Lawrence Honig, Jennifer Hui, Diana Kerwin, Akio Kikuchi, Thomas Kimber, Takashi Kimura, Rajeev Kumar, Irene Litvan, Peter Ljubenkov, Stefan Lorenzl, Albert Ludolph, Zoltan Mari, Nikolaus McFarland, Wassilios Meissner, Pablo Mir Rivera, Hidek Mochizuki, John Morgan, Renato Munhoz, Noriko Nishikawa, John O'Sullivan, Tomoko Oeda, Hideki Oizumi, Osamu Onodera, Fabienne Ory‐Magne, Elizabeth Peckham, Ronald Postuma, Aldo Quattrone, Joseph Quinn, Stefano Ruggieri, Justyna Sarna, Paul E. Schulz, John Slevin, Michele Tagliati, Daryl Wile, Zbigniew Wszolek, Tao Xie, Theresa Zesiewicz, Juan C. Gómez, Beatriz Tijero, Rafael Villoria, Justo García de Yebenes, Jose L. Sendón, Eduardo Tolosa, Maria T. Buongiorno, Nuria Bargalló, Juan A. Burguera, Iñiguez Martinez, Javier Ruiz‐Martínez, Jorge Villanua, Francisco Vivancos, Isabel Ybot, Miquel Aguilar, Josep L. Dolz, Mercè Boada, Asuncion Lafuente, Miguel A. Tejero, Juan J. López‐Lozano, Marina Mata, Andreas Kupsch, Axel Lipp, Matthias Höllerhage, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Susanne Knake, Daniela Berg, Walter Maetzler, Karin K. Srulijes, Adriane Gröger, Albert Ludolph, Jan Kassubek, Malcom Steiger, Kevin Tyler, David J. Burn, Cristopher Morris, Andrew Lees, Helen Ling, Lisa Strycharczuk, Slawek Altenstein, Mathias Baehr, Miriam Barkhoff, Claudia Bartels, Bartl Michael, Rudi Beschorner, Eberhard Karls, Aline Beyle, Henning Boecker, Moritz Brandt, Kathrin Brockmann, Frederic Brosseron, Lena Burow, Cihan Catak, Arda Can Cetindag, Nicoleta Carmen Cosma, Marcel Daamen, Eman Dashti, Sylvia de Jonge, Peter Dechent, Martin Dichgans, Elisabeth Dinter, Laura Dobisch, Angelika Dörr, Markus Donix, Louisa Droste zu Senden, Alexander Drzezga, Emrah Düzel, Martin Dyrba, Marie Ehrlich, Matthias Endres, Tanja Engels, Ersin Ersözlü, Michael Ewers, Jennifer Faber, Björn Falkenburger, Frederike Fenski, Klaus Fließbach, Agnes Flöel, Silka Dawn Freiesleben, Franca Laura Fries, Ingo Frommann, Thomas Gasser, Wenzel Glanz, Doreen Goerss, Doreen Grieger‐Klose, Marcus Grobe‐Einsler, Martin Grond, Selim Üstün Gürsel, Annett Halle, Niels Hansen, Deike Hartmann, Lina Hassoun, Robert Haussmann, Julian Hellmann‐Regen, Guido Hennes, Wiebke Hermann, Andreas Hermann, Jochen Herms, Gabi Herrmann, Stefan Hetzer, Petra Hinderer, Günther U. Höglinger, Ildiko Horvath, Nicole Hujer, Enise Irem Incesoy, Alexander Jäck, Daniel Janowitz, Frank Jessen, Lorraine Jost, Pascal Kalbhen, Jan Kassubek, Sabrina Katzdobler, Ingo Kilimann, Okka Kimmich, Luca Kleinadam, Thomas Klockgether, Xenia Kobeleva, Patricia Krause, Elke Kuder‐Buletta, Andrea Kühn, Carolin Kurz, Catharina Lange, Chris Lappe, Christoph Laske, Johannes Levin, Sandra Lichte Schneider, Paul Lingor, Matthias Löhle, Albert C. Ludolph, Falk Lüsebrink, Cornelia McCormick, David Mengel, Coraline Metzger, Matthias Munk, Manuela Neumann, Demet Oender, Robert Perneczky, Oliver Peters, Gabor C. Petzold, Henrike Pfaff, Alexandra Polcher, Lukas Preis, Josef Priller, Johannes Prudlo, Dominik Pürner, Veronika Purrer, Boris Rauchmann, Alfredo Ramirez, Heike Raum, Sandra Röske, Christin Ruß, Petr Sabik, Yilmaz Sagik, Klaus Scheffler, Monika Schmidt, Anja Schneider, Luisa‐Sophie Schneider, Ludger Schoels, Björn Schott, Heike Schulz, Franziska Schulze, Sebastian Sodenkamp, Annika Spottke, Eike Spruth, Melina Stark, Matthis Synofzik, Patricia Sulzer, Stefan Teipel, Ina R Vogt, Michael Wagner, Endy Weidinger, Carlo Wilke, Jens Wiltfang, Steffen Wolfsgruber, Ullrich Wüllner, Renat Yakupov, Heike Zech, Inga Zerr, Gabriel Ziegler, Adelgunde Zollver, Günter U. Höglinger +424 morewiley +1 more sourceDiagnostic challenges in multiple system atrophy
Neuropsychiatric Disease and Treatment, 2018 Diana Obelieniene,1 Sandra Bauzaite,1 Ilona Kulakiene,2 Evaldas Keleras,2 Indre Eitmonaite,3 Daiva Rastenyte1 1Department of Neurology, 2Department of Radiology, 3Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania Abstract ...Obelieniene D, Bauzaite S, Kulakiene I, Keleras E, Eitmonaite I, Rastenyte D +5 moredoaj Immunotherapy in progressive supranuclear palsy
Current Opinion in Neurology, 2020 Purpose of review Progressive supranuclear palsy (PSP) is a progressive adult-onset neurodegenerative disease. Abnormally, phosphorylated forms of the microtubule-associated protein tau containing four repeat domains (4R-tau) aggregate in neurons. Additionally, increasing evidence suggests that secretion and uptake of fragments Pavan A. Vaswani, Abby L. Olsenopenaire +4 more sourcesAZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression
Movement Disorders, EarlyView.Abstract Objectives
The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rare tauopathy. Methods
A randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted at Jean‐Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Günter Höglinger, Marie Lebouteux, Graziella Mangone, Noelle Callizot, Aurélien Blondel, Olivier Defert, Cecilia Estrella, Artin Karapet, Philippe Verwaerde, Luc Defebvre +17 morewiley +1 more sourceEarly-stage [123I]beta-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease [PDF]
, 2005 beta-CIT binding in both caudate nuclei was lower than in the group of patients with IPD. In addition, putamen to caudate binding ratios were higher in the group of APS patients.A Antonini, A Varrone, AH Rajput, AJ Hughes, AJ Hughes, AJ Hughes, Ania Winogrodzka, C Messa, Diederick Stoffers, E Nurmi, Erik C. Wolters, G Tissingh, G Tissingh, G Tissingh, H Bernheimer, Henk W. Berendse, I Litvan, IG McKeith, J Booij, J Schwarz, Jan Booij, JE Ahlskog, JP Seibyl, KL Marek, Lisette Bosscher, M Ruberg, MM Hoehn, N Ilgin, RB Innis, RB Innis, S Asenbaum, S Gilman, S Goto, SJ Kish, SJ Kish, T Brücke, W Pirker, W Pirker, WR Gibb, YJ Kim +39 morecore +1 more sourceProgressive supranuclear palsy [PDF]
Neurology, 2008 In the article, “Tau forms in CSF as a reliable biomarker for progressive supranuclear palsy,” Dr. Borroni and her coauthors ( Neurology ®2008;71:1796–1803) looked at specific medical tests that could help physicians accurately diagnose this illness.openaire +2 more sourcesA Biomarker‐Based Classification of Corticobasal Syndrome
Movement Disorders, EarlyView.Abstract Background
Corticobasal syndrome (CBS) is a clinically defined syndrome with progressive movement and cortical dysfunction, caused by various underlying pathologies, most commonly tau‐predominant pathologies such as progressive supranuclear palsy and corticobasal degeneration, or Alzheimer's disease (AD).Carla Palleis, Alexander Maximilian Bernhardt, Endy Weidinger, Urban M. Fietzek, Alexander Jäck, Sabrina Katzdobler, Johannes Gnörich, Theresa Bauer, Nicolai Franzmeier, Robert Perneczky, German Imaging Initiative for Tauopathies (GII4T), Matthias Brendel, Johannes Levin, Günter U. Höglinger +13 morewiley +1 more source
