Results 71 to 80 of about 15,560 (165)

The binaural masking level difference: cortical correlates persist despite severe brain stem atrophy in progressive supranuclear palsy. [PDF]

, 2014
Under binaural listening conditions, the detection of target signals within background masking noise is substantially improved when the interaural phase of the target differs from that of the masker.
Carlyon, Robert P, Ghosh, Boyd CP, Gockel, Hedwig E, Hughes, Laura E, Plack, Christopher J, Rowe, James B   +5 more
core   +3 more sources

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. [PDF]

PLoS ONE, 2018
Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau.
Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasson   +6 more
doaj   +1 more source

Dysphagia in Progressive Supranuclear Palsy

Dysphagia, 2019
Progressive supranuclear palsy (PSP) is the most common Parkinson-Plus syndrome and is associated with early onset of dysphagia relative to Parkinson Disease. The current study contributes to the growing understanding of swallowing dysfunction in PSP by describing oropharyngeal swallowing characteristics in a large prospective cohort of participants ...
Heather M. Clark, Farwa Ali, Julie A.G. Stierwalt, Nirubol Tosakulwong, Jennifer L. Whitwell, Keith A. Josephs, Hugo Botha   +6 more
openaire   +4 more sources

Efficacy and Safety of IncobotulinumtoxinA for Treatment of Sialorrhea: A Multicenter, Phase 3 Study in Japan

Movement Disorders Clinical Practice, EarlyView.
This study demonstrated significant treatment efficacy and safety of incobotulinumtoxinA injection in Japanese patients with chronic sialorrhea caused by Parkinson's disease and other neurological conditions. Suppression of salivary secretion and improvement in drooling symptoms were also observed throughout 48 weeks.
Nobutaka Hattori, Yohei Mukai, Noriko Nishikawa, Kazuko Hasegawa, Masahiko Tomiyama, Yasuyoshi Kimura, Yoshio Tsuboi, Ryosuke Takahashi, Ryota Nakamura, Yuishin Izumi, Hirohisa Watanabe, Morinobu Seki, Kenji Sekiguchi, Shohei Tateishi, Yusaku Matsushita, Yusaku Nakamura   +15 more
wiley   +1 more source

Pilot Study of [¹¹C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer

Cells
A novel brain positron emission tomography (PET) radioligand, [11C]HY-2-15, has potential for imaging alpha-synuclein aggregations in multiple system atrophy and misfolded tau proteins in tauopathies, based on its high binding affinity in disease brain ...
Chia-Ju Hsieh, Dinahlee Saturnino Guarino, Anthony J. Young, Andrew D. Siderowf, Ilya Nasrallah, Alexander Schmitz, Carol Garcia, Ho Young Kim, Erin K. Schubert, Hsiaoju Lee, Joel S. Perlmutter, Robert H. Mach   +11 more
doaj   +1 more source

Clinical heterogeneity of progressive supranuclear palsy

Анналы клинической и экспериментальной неврологии, 2018
Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative disease characterized by oculomotor disorders, early onset of postural instability and cognitive dysfunction.
Alexey A. Tappakhov, Tatiana E. Popova, Tatiana G. Govorova, Alyona Yu. Petrova   +3 more
doaj   +1 more source

Progression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials [PDF]

, 2023
The advent of clinical trials of disease-modifying agents for neurodegenerative disease highlights the need for evidence-based endpoint selection.
Allinson, Kieren SJ, Ansorge, Olaf, Bocchetta, Martina, Burn, David J, Chelban, Viorica, Church, Alistair, Costantini, Alyssa, Gerhard, Alexander, Goh, Yen Y, Guo, Tong, Heslegrave, Amanda J, Holland, Negin, Houlden, Henry, Hu, Michele TM, Jabbari, Edwin, Jaunmuktane, Zane, Jensen, Marte T, Jones, P Simon, Klein, Johannes C, Kobylecki, Christopher, Lees, Andrew J, Leigh, P Nigel, Morris, Huw, Pavese, Nicola, Revesz, Tamas, Rittman, Timothy, Rohrer, Jonathan D, Roncaroli, Federico, Rowe, James B, Russell, Lucy L, Street, Duncan, Warner, Thomas T, Zetterberg, Henrik   +32 more
core  

Serious Illness Conversation in the Care of Atypical Parkinsonian Disorders: A Practical Guide for Neurology Clinicians

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Compared to Parkinson's disease, atypical parkinsonian disorders (APD) are characterized by a more rapidly progressive course, often leading to profound disability. Effective communication between clinicians, patients, and care partners is essential to support patient‐centered care and shared decision‐making.
Michiko K. Bruno, Jocelyn Jiao, Neha M. Kramer, Margaret Ivancic, Claudia Chou, Jessica Shurer, Thomas Carroll, on behalf of CurePSP Centers of Care Palliative Care Working Group   +7 more
wiley   +1 more source

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +4 more sources

An Exploration of the High Prevalence of Parkinson's Disease in a Rural Area of North West England

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Globally the prevalence of Idiopathic Parkinson's Disease (IPD) is rising. Increasing recognition is being given to the influence of environmental factors on this rise, although the precise impact of such factors remains poorly understood.
Rosanna Varden, Ailish O'Callaghan, Richard Walker   +2 more
wiley   +1 more source