Osmoregulation and the Hypothalamic Supraoptic Nucleus: From Genes to Functions [PDF]
Frontiers in Physiology, 2022 Due to the relatively high permeability to water of the plasma membrane, water tends to equilibrate its chemical potential gradient between the intra and extracellular compartments.
André Souza Mecawi +2 more
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The importance of oxytocin neurons in the supraoptic nucleus for breastfeeding in mice. [PDF]
PLoS ONE, 2023 The hormone oxytocin, secreted from oxytocin neurons in the paraventricular (PVH) and supraoptic (SO) hypothalamic nuclei, promotes parturition, milk ejection, and maternal caregiving behaviors. Previous experiments with whole-body oxytocin knockout mice
Mitsue Hagihara +2 more
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Whole transcriptome organisation in the dehydrated supraoptic nucleus [PDF]
Brazilian Journal of Medical and Biological Research, 2013 The supraoptic nucleus (SON) is part of the central osmotic circuitry that synthesises the hormone vasopressin (Avp) and transports it to terminals in the posterior lobe of the pituitary.
C.C.T. Hindmarch +3 more
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Expression of exocytosis proteins in rat supraoptic nucleus neurones. [PDF]
J Neuroendocrinol, 2012 In magnocellular neurones of the supraoptic nucleus (SON), the neuropeptides vasopressin and oxytocin are synthesised and packaged into large dense‐cored vesicles (LDCVs). These vesicles undergo regulated exocytosis from nerve terminals in the posterior pituitary gland and from somata/dendrites in the SON. Regulated exocytosis of LDCVs is considered to
Tobin V +5 more
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Microdissection of the supraoptic nucleus and posterior pituitary gland from fresh unfixed tissue [PDF]
MethodsX, 2023 The rat supraoptic nucleus (SON) contains magnocellular neurons that project long axons that terminate in the posterior pituitary gland. To perform molecular characterization of these regions, such as transcriptome and methylome profiling, it is ...
Derick Thompson +2 more
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Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways [PDF]
Biology of Sex Differences, 2023 Background The supraoptic nucleus (SON) of the hypothalamus contains magnocellular neurosecretory cells that secrete the hormones vasopressin and oxytocin. Sex differences in SON gene expression have been relatively unexplored.
Dianna H. Nguyen +4 more
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Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity [PDF]
Frontiers in Aging Neuroscience, 2023 The age-dependent loss of neuronal plasticity is a well-known phenomenon that is poorly understood. The loss of this capacity for axonal regeneration is emphasized following traumatic brain injury, which is a major cause of disability and death among ...
Derick Thompson +3 more
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Age-dependent increase in Thy-1 protein in the rat supraoptic nucleus [PDF]
Heliyon, 2020 Mature mammalian CNS neurons often do not recover successfully following injury. To this point, unilateral lesion of the hypothalamo-neurohypophysial tract results in collateral sprouting from uninjured axons of the supraoptic nucleus (SON) in 35-day-old
Jason M. Askvig +12 more
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Vasopressin and oxytocin expression in hypothalamic supraoptic nucleus and plasma electrolytes changes in water-deprived male Meriones libycus [PDF]
Animal Cells and Systems, 2021 In mammals, plasmatic osmolality needs to be stable, and it is highly related to the hydric state of the animals which depends on the activity of the hypothalamic neurohypophysial system and more particularly by vasopressin secretion.
Lydia Boumansour +6 more
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Osmotic perception of GABAergic synaptic transmission in the supraoptic nucleus of rats [PDF]
IBRO Reports, 2020 Extracellular osmolality plays a crucial role in controlling the activation of neurons. Hypertonic stimulation modulates glutamatergic inputs to the supraoptic nucleus (SON) magnocellular neurosecretory cells (MNCs) putative vasopressin (VP) neurons ...
Toyoaki Ohbuchi +6 more
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