Results 41 to 50 of about 5,579,081 (261)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Acerca de la Etnoarqueología en América del Sur
Horizontes Antropológicos, 2002 La Etnoarqueología es una disciplina de desarrollo aun muy limitado en América del Sur a pesar del potencial de la región para este tipo de investigaciones.
Gustavo G. Politis
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MedwaveIntroduction Bariatric and metabolic surgery is a safe and effective method for treating clinically severe obesity. In Argentina, Law 26 396 and its amendments establish the regulatory framework for its coverage.
Paulina Siciliani +2 more
doaj +1 more source
, 2023 La Conferencia Regional sobre Cooperación Sur-Sur de América Latina y el Caribe fue creada por los países miembros de la CEPAL en diciembre de 2021, durante el trigésimo sexto período de sesiones del Comité Plenario de la Comisión regional de las ...
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Carta Internacional, 2018 La I Conferencia Ministerial del Foro China-CELAC que se llevó a cabo los días 8 y 9 de enero de 2015 en Beijing y el Policy Paper de la República Popular de China (RPC) para América Latina y el Caribe (ALC) de 2016 se tornaron los marcos institucionales
Javier Alberto Vadell
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Monções, 2019 El alto nivel de exposición y vulnerabilidad a los desastres de origen natural en la región Latinoamericana y el Caribe, han generado en no pocas ocasiones un impacto directo en la movilidad humana.
Juan Carlos Méndez Barquero
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source