Results 61 to 70 of about 5,579,081 (261)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Hispania Sacra, 2002 Estudio y síntesis de la evangelización cristiana en el Nuevo Mundo y la recepción del evangelio por las poblaciones indígenas americanas, en especial mesoamericanas, durante la época colonial y en los primeros siglos de la independencia.
Jesús María García Añoveros
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
THE MANAGEMENT OF VISIBLE AND INVISIBLE DIVERSITY IN ORGANIZATIONS
Visión de FuturoThe objectives of this article are to review the literature of Sixty-three (63) documents on the management of visible and invisible diversity in organizations, for which a tour of the background is carried out, the concept of diversity; the legitimacy ...
Manuel Alfonso Garzón Castrillon
doaj +1 more source
La cooperación venezolana en América Latina: de la retórica a la acción
América Latina Hoy, 2013 Este trabajo se propone analizar la coherencia entre el discurso existente en torno a la Cooperación Sur-Sur y la acción práctica de Venezuela en América Latina y Caribe.
María RODRÍGUEZ GARCÍA
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Episteme, 2012 La definición de cooperación Sur-Sur es aun ambigua si se tiene en cuenta que su naturaleza y principios obedecen a los cambios sociales, económicos y culturales que se suscitan en el orden mundial donde los países menos desarrollados son protagonistas.
Edwar Ramírez Castellanos
doaj +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Resumen del Ciclo de webinarios del Observatorio América Latina - Asia Pacífico
, 2021 Observatorio América Latina - Asia Pacífico.Introducción -- Programa del ciclo -- Resumen ejecutivo de los contenidos del ciclo de webinarios: 1. América Latina y Asia Pacífico: Acuerdos y relaciones comerciales -- 2.
core +1 more source