Results 51 to 60 of about 49,084 (266)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Carta Internacional, 2018 La I Conferencia Ministerial del Foro China-CELAC que se llevó a cabo los días 8 y 9 de enero de 2015 en Beijing y el Policy Paper de la República Popular de China (RPC) para América Latina y el Caribe (ALC) de 2016 se tornaron los marcos institucionales
Javier Alberto Vadell
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Mapa de la costa occidental de Sur América
, 2015 Carta de la costa occidental de Sur América con la ruta prevista para los vapores desde Chile hasta Panamá. [s.l.
[s.n.]
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MedwaveIntroduction Bariatric and metabolic surgery is a safe and effective method for treating clinically severe obesity. In Argentina, Law 26 396 and its amendments establish the regulatory framework for its coverage.
Paulina Siciliani +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Relaciones entre África y Centro-Sur América
, 2010 El presente artículo aborda las relaciones entre África y Centro-Sur América desde una perspectiva histórica, política y socioeconómica, resaltando la importancia de unir los pueblos y los Estados de los dos continentes con el objetivo de equilibrar las ...
Vargas Olarte, Daniel Alejandro
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Vicente Rodríguez Valencia Pbro., Santo Toribio de Mogrovejo, organizador y apóstol de Sur-América.
, 1959 Ricard Robert. Vicente Rodríguez Valencia Pbro., Santo Toribio de Mogrovejo, organizador y apóstol de Sur-América.. In: Bulletin Hispanique, tome 61, n°1, 1959. pp.
Ricard, Robert
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Reforma del sector salud y la política farmacéutica en Perú
Cadernos de Saúde PúblicaEste artículo analiza el Programa de Administración Compartida de Farmacias (PACFARM) y su articulación con la Política Farmacéutica en Perú, en el contexto de la reforma del sector salud. La ejecución de los diversos Programas de Medicamentos Esenciales
Carmen Phang Romero
doaj +2 more sources