Results 101 to 110 of about 55,425 (314)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

CHRISTIAN DEBLOCK, JOËL LEBULLENGER ET STÉPHANE PAQUIN, DIR, UN NOUVEAU PONT SUR L’ATLANTIQUE : L’ACCORD ÉCONOMIQUE ET COMMERCIAL GLOBAL ENTRE L’UNION EUROPÉENNE ET LE CANADA, QUÉBEC, PRESSES DE L’UNIVERSITÉ DU QUÉBEC, 2015 [PDF]

, 2015
Laurence Marquis
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Los estudios comparativos en el campo de la investigación urbana*

Estudios Demográficos y Urbanos
Este trabajo examina el papel del método comparativo en la investigación urbana, prestando atención a su utilidad en la generación de teoría, y a las particularidades de las comparaciones entre ciudades de distintas regiones.
Martha Schteingart, Andrés Sierra
doaj   +1 more source

China en el orden liberal internacional: debates globales y lecturas desde América del Sur

, 2023
María Florencia Rubiolo, Gonzalo Fiore-Viani   +1 more
openalex   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

De CINVA a Siyabuswa: el trayecto errático de la vivienda de autoayuda global

ARQ
En un proyecto piloto para la futura capital Bantustán en Siyabuswa, el estado sudafricano de la era del apartheid financió la investigación y construcción de 59 viviendas básicas entre 1977 y 1978, antes de frenar el esquema completo.
Hannah le Roux
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

colonialidad del Derecho administrativo global: una crítica interdisciplinaria desde el sur global

Revista de Derecho Público: Teoría y método
La idea de Derecho Administrativo Global es universalista porque se funda sobre la noción de un conjunto de principios comunes a todas las tradiciones de derecho administrativo. Desde el punto de vista de la crítica decolonial ese postulado es problemático y amerita una serie de críticas teóricas que no impiden formular una eventual solución: la ...
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source