Results 111 to 120 of about 4,143,872 (340)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Seismic Fragility Curves of RC Buildings Subjected to Aging
GeoHazardsA large number of existing reinforced concrete (RC) buildings have surpassed their anticipated service life and show signs of degradation due to aging; this degradation is a function of the construction practices adopted in the past as well as ...
Spyridon Diamantopoulos +4 more
doaj +1 more source
A survey on OFDM channel estimation techniques based on denoising strategies
Engineering Science and Technology, an International Journal, 2017 Channel estimation forms the heart of any orthogonal frequency division multiplexing (OFDM) based wireless communication receiver. Frequency domain pilot aided channel estimation techniques are either least squares (LS) based or minimum mean square error
Pallaviram Sure, Chandra Mohan Bhuma
doaj +1 more source
Sure Start Blacon reach report, April 2004 - March 2005 [PDF]
, 2006 This project report discusses Sure Start computerised records (covering personal details of all registrations within the Sure Start programme and records of each serivce and which service users have accessed them) which allow the 'reach' of the local ...
Alford, Simon +3 more
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Missed Opportunities of Janani Suraksha Yojana Benefits Among the Beneficiaries in Slum Areas
National Journal of Community Medicine, 2011 In 2005, with the goal of reducing the numbers of maternal and neonatal deaths, the Government of India launched Janani Suraksha Yojana (JSY), a conditional cash transfer scheme, to incentivize women to give birth in a health facility.
Wadgave Hanmanta Vishwanath +2 more
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Sure Start Mellow Valley area Through the lens of a camera [PDF]
, 2007 This report gives an account of a participatory evaluation conducted using photography within the Sure Start Mellow Valley area. Information about the current status of the Sure Start programme and the plans for the future are first provided.
Cross, RM +3 more
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source