Results 61 to 70 of about 669,796 (280)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Institutional Abuse, Neglect and Harm in UK Community Mental Health Services: A Scoping Review of the Peer‐Reviewed Evidence

Health Expectations
Background Statutory guidance relating to the prevention of institutional abuse, neglect and harm does not reflect the contemporary organisation of UK community mental health services.
Bethan M. Edwards, Alan Meudell, Ellen Thomas, Eva Broeckelmann, Eva Roberts, Mark Farmer, Naomi Ghafoor, Sarah Markham, Catherine A. Robinson, Angela Sweeney, Sarah Carr, Michael Clark   +11 more
doaj   +1 more source

Hope and meaning-making in phase 1 oncology trials: a systematic review and thematic synthesis of qualitative evidence on patient-participant experiences

Trials, 2022
Background Phase 1 drug trials are popular treatment options for patients with advanced disease, despite the greater levels of uncertainty associated with them. However, their meaning and consequences for patient-participants remains under-explored. This
Kate Escritt, Mala Mann, Annmarie Nelson, Emily Harrop   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Theodor Nöldeke’nin Âyet ve Sûreleri Tarihlendirmede Başvurduğu Yöntemlere Eleştirel Bir Yaklaşım / Approach to the Methods of Theodor Nöldeke in Dating Verses and the Surahs-I / مقاربة نقدية لوسائل تيودور نولدكه في تأريخ الآيات والسور- 1

İlahiyat Akademi, 2019
Oryantalistlerin nazarında Kur’an-ı Kerim’in mevcut mushaf tertibi, O’nun kompozisyon bütünlüğünden yoksun olmasına ve anlaşılmamasına neden olan başat unsurdur.
Hüseyin Polat
doaj  

But surely [PDF]

British Dental Journal, 2021
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Sure Start Widnes Children’s Centres: An evaluation of a new programme [PDF]

, 2007
This project reports evaluates the publicity material created and used by Sure Start Widnes Children's ...
Alford, Simon, Powell, Katie, Perry, Catherine   +2 more
core   +2 more sources

BİR TEFSİR DERSİ ÖRNEGİ

Cumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2012
Bu yazıda aktif olarak işlenen bir tefsir dersi tecrübesi aktarılmaktadır. 2012-2013 öğretim yılında ilahiyat Fakültesi III. sınıfta yapılan derste, öğrencilere daha fazla rol verilerek azami fayda sağlanmak hedeflenmiştir.
İSMAİL ÇALIŞKAN
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source