Results 81 to 90 of about 4,143,872 (340)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Improving Quality of Care in Primary Health-Care Facilities in Rural Nigeria

open access: yesHealth Services Research & Managerial Epidemiology, 2016
Background: Nigeria has a high population density but a weak health-care system. To improve the quality of care, 3 organizations carried out a quality improvement pilot intervention at the primary health-care level in selected rural areas.
Okoli Ugo   +5 more
doaj   +1 more source

Maximum Power Point Tracking of Photovoltaic System for Traffic Light Application

open access: yesJournal of Mechatronics, Electrical Power, and Vehicular Technology, 2013
Photovoltaic traffic light system is a significant application of renewable energy source. The development of the system is an alternative effort of local authority to reduce expenditure for paying fees to power supplier which the power comes from ...
Riza Muhida   +4 more
doaj   +1 more source

Blacon Sure Start parent satisfaction survey [PDF]

open access: yes, 2003
This report evaluates Sure Start in Blacon during 2003.Commissioned and funded by Blacon Sure ...
Barrow, Marjorie   +2 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sure Start Children's Centres: statutory guidance [PDF]

open access: yes, 2010
"References in this document to ‘the Childcare Act’ mean the Childcare Act 2006, as amended by the Apprenticeships, Skills, Children and Learning Act 2009 (the ASCL Act) unless specified otherwise. This guidance is made under the Childcare Act.

core  

An almost sure energy inequality for Markov solutions to the 3D Navier-Stokes equations

open access: yes, 2009
We prove existence of weak martingale solutions satisfying an almost sure version of the energy inequality and which constitute a (almost sure) Markov process.Comment: Submitted for the proceedings of the conference "Stochastic partial differential ...
Romito, Marco
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Hope and meaning-making in phase 1 oncology trials: a systematic review and thematic synthesis of qualitative evidence on patient-participant experiences

open access: yesTrials, 2022
Background Phase 1 drug trials are popular treatment options for patients with advanced disease, despite the greater levels of uncertainty associated with them. However, their meaning and consequences for patient-participants remains under-explored. This
Kate Escritt   +3 more
doaj   +1 more source

SURE: A method for decision-making under uncertainty

open access: yesExpert systems with applications, 2019
Managerial decision-making often involves the consideration of multiple criteria with high levels of uncertainty. Multi-attribute utility theory, a primary method proposed for decision-making under uncertainty, has been repeatedly shown to be difficult ...
R. Hodgett, S. Siraj
semanticscholar   +1 more source

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