Results 81 to 90 of about 395,686 (299)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

‘Open Access’ or ‘Open Excess’?: libraries at a crossroads

Insights: The UKSG Journal, 2015
Comparing the costs of open access (OA) and subscriptions is a hot topic at the present time. However, the results of such comparisons often raise questions. This article attempts to provide a more systematic analysis in the form of a question and answer
Leo Waaijers
doaj   +1 more source

The calibration of photographic and spectroscopic films. The utilization of the digital image processor in the determination of aging of the surf clam (Spisula solidissima) [PDF]

The age of the surf clam (Spisula solidissima) can be determined with the use of the Digital Image Processor. This technique is used in conjunction with a modified method for aging, refined by John Ropes of the Woods Hole Laboratory, Massachusetts.
Hammond, Ernest C., Jr., Peters, Kevin A.   +1 more
core   +1 more source

ALT-SURF seminar: ePortfolios and Digital Repositories, 22 and 23 April 2004, Edinburgh UK [PDF]

, 2004
ALT (Association for Learning Technology) and SURF (collaborative organisation for IT innovation in Dutch HE) have similar goals and started working together in 1999.
Littlejohn, Allison
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Transcript of The Blimp Encounter [PDF]

, 2011
This story is an excerpt from a longer interview that was collected as part of the Launching through the Surf: The Dory Fleet of Pacific City project. In this story, Al Jensen recounts the experience of encountering a Navy blimp while fishing with his ...
Jensen, Allan
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Transcript of Battle Stations [PDF]

, 2011
This story is an excerpt from a longer interview that was collected as part of the Launching through the Surf: The Dory Fleet of Pacific City project.
Cellers, Michael W.
core   +1 more source

Projected WIMP sensitivity of the LUX-ZEPLIN dark matter experiment [PDF]

, 2020
LUX-ZEPLIN (LZ) is a next-generation dark matter direct detection experiment that will operate 4850 feet underground at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. Using a two-phase xenon detector with an active mass of 7
Akerib, DS, Akerlof, CW, Alsum, SK, Araújo, HM, Arthurs, M, Bai, X, Bailey, AJ, Balajthy, J, Balashov, S, Bauer, D, Belle, J, Beltrame, P, Benson, T, Bernard, EP, Biesiadzinski, TP, Boast, KE, Boxer, B, Brás, P, Buckley, JH, Bugaev, VV, Burdin, S, Busenitz, JK, Carels, C, Carlsmith, DL, Carlson, B, Carmona-Benitez, MC, Chan, C, Cherwinka, JJ, Cole, A, Cottle, A, Craddock, WW, Currie, A, Cutter, JE, Dahl, CE, De Viveiros, L, Dobi, A, Dobson, JEY, Druszkiewicz, E, Edberg, TK, Edwards, WR, Fan, A, Fayer, S, Fiorucci, S, Fruth, T, Gaitskell, RJ, Genovesi, J, Ghag, C, Gilchriese, MGD, Hall, CR, Hans, S, Hanzel, K, Haselschwardt, SJ, Hertel, SA, Hillbrand, S, Hjemfelt, C, Hoff, MD, Hor, JYK, Huang, DQ, Ignarra, CM, Ji, W, Kaboth, AC, Kamdin, K, Keefner, J, Khaitan, D, Khazov, A, Kim, YD, Kocher, CD, Korolkova, EV, Kraus, H, Krebs, HJ, Kreczko, L, Krikler, B, Kudryavtsev, VA, Kyre, S, Lee, J, Lenardo, BG, Leonard, DS, Lesko, KT, Levy, C, Li, J, Liao, FT, Liao, J, Lin, J, Lindote, A, Linehan, R, Lippincott, WH, Liu, X, Lopes, MI, Lorenzon, W, Luitz, S, Lyle, JM, López Paredes, B, Majewski, P, Manalaysay, A, Mannino, RL, Maupin, C, McKinsey, DN, Meng, Y, Miller, EH, Van Der Grinten, MGD   +99 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source