Results 71 to 80 of about 9,174,816 (293)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The effect of diluted 1% baby shampoo on biofilm reduction in chronic rhinosinusitis with nasal polyposis [PDF]

PeerJ
Background Biofilm has been identified as the contributing factor for refractory chronic rhinosinusitis with nasal polyposis (CRSwNP). Nasal douching using baby shampoo was thought to be effective in patients with CRSwNP.
Farah Dayana Zahedi, Mun Yee Soo, Muttaqillah Najihan Abdul Samat, Suria Hayati Md Pauzi, Salina Husain, Aneeza Khairiyah Wan Hamizan, Baharudin Abdullah, Balwant Singh Gendeh, Abdul Samat Ismail, Rocky Vester Richmond   +9 more
doaj   +2 more sources

The Jones-Ray Effect Is Not Caused by Surface Active Impurities [PDF]

, 2018
Pure aqueous electrolyte solutions display a minimum in surface tension at concentrations of ~ 2 mM. This effect has been a source of controversy since first reported by Jones and Ray in the 1930s.
Sylvie, Roke, Chad, Drexler, Halil I., Okur, Paul S., Cremer, Eric, Tyrode   +4 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Antifungal Activities of Streptomyces blastmyceticus Strain 12-6 Against Plant Pathogenic Fungi

Mycobiology, 2019
Streptomyces blastmyceticus strain 12-6 was isolated from a forest soil sample of Cheonan area on the basis of strong antifungal activities against plant pathogenic fungi. Butanol extracts of the cultural filtrates were active against C.
Yeon Ju Kim, Jae-heon Kim, Jae-Young Rho
doaj   +1 more source

Transportation Development Division, Active Transportation Section, March 1, 2013 [PDF]

, 2013
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on April 11, 2014)Mode of ...

core  

Bioremediation of crude oil contamination using microbial surface-active agents: isolation, production and characterization

, 2010
The present study highlights isolation, screening, production, characterization of marine microbial surface active agents followed by evaluating the efficacy of said surface -active agents for bioremediation of crude oil contamination.
Kavitha, Varadharajan, Radhakrishnan, Narayanasamy, Gnanamani, Arumugam, Mandal, Asit Baran   +3 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Surface Active Agents [PDF]

Soil Science, 1946
C. B. F. YOUNG, K. W. COONS
  +5 more sources

Fabrication and Frosting Properties Study of Surface-Active Agents Coating Based on Nanoporous Aluminum Substrate

Energies, 2018
In order to solve the frosting and blockage problem of an air conditioning evaporator’s fin in winter, the nanoporous aluminum plates with low surface energy has been proposed in this paper, which are fabricated by an anodizing method and then ...
Song He, Yanmei Zhang, Wansheng Yang, Xudong Zhao, Bin Zeng   +4 more
doaj   +1 more source