Results 41 to 50 of about 391,322 (266)

Biocompatibility Evaluation of Surface-Modified Orthodontic Wires Using Graphene Layer

International Journal of Molecular Sciences
The biocompatibility of orthodontic archwires is crucial for ensuring patient safety and the long-term success of orthodontic treatment. This study evaluated the biocompatibility of stainless steel (SS) and nickel–titanium (Ni-Ti) orthodontic archwires, as well as stainless steel metal brackets, before and after the application of a graphene coating ...
Joanna Rygas, Maria Szymonowicz, Agnieszka Rusak, Magdalena Wawrzyńska, Piotr Kuropka, Vitalii Boiko, Bartosz Mielan, Dariusz Hreniak, Maciej Dobrzyński   +8 more
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Study of the Surface Structural Transformation and Mechanical Properties of 65Mn Steel Modified by Pulsed Detonation–Plasma Technology

Metals
Pulsed detonation–plasma technology (PDT) is a surface-modification technology used in an atmospheric environment, where plasma, a detonation impact and thermal conditions are combined and have an effect on the material’s surface. In this study, annealed
Youxing He, Mingming Zhang, Xuebing Yang, Wenfu Chen, Lei Lu   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Modeling the antifouling properties of atomic layer deposition surface-modified ceramic nanofiltration membranes

Biofouling, 2022
This work investigates the enhancement of antifouling properties of ceramic nanofiltration membranes by surface modification via atomic layer deposition (ALD) of TiO2. Feed solutions containing bovine serum albumin (BSA), humic acid (HA) and sodium alginate (SA) were used as model foulants.
Welldone Moyo, Nhamo Chaukura, Machawe M. Motsa, Titus A. M. Msagati, Bhekie B. Mamba, Sebastiaan G. J. Heijman, Thabo T. I. Nkambule   +6 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Fire-protection of wooden structures by modification in a thin surface layer

MATEC Web of Conferences, 2018
The mechanism of fire protection of wood by the modification of a thin surface layer with organophosphorus compounds has been studied. The properties of the modified thin surface layer were studied by X-ray spectral analysis, IR spectroscopy and ...
Pokrovskaya Elena
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Modification mechanism of Cu–Al alloy with pre-cladded Al/AlY layers treated by plasma nitriding: Experiments and first-principles calculations

Journal of Materials Research and Technology
The improvement in the properties of aluminum bronze alloys after nitriding is limited due to the immiscibility of nitrogen atoms with the copper matrix. To address this issue, a Cu-Al intermetallic compound prelayer is used, and the rare earth element Y
Xiaoxian Li, Lingling Liu, Xiang Wang, Xuehui Zhang, Tongxiang Liang   +4 more
doaj   +1 more source