Results 101 to 110 of about 4,631,256 (302)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients
Respiratory Research, 2005 Background In a cross-sectional analysis of cystic fibrosis (CF) patients with mild lung disease, reduced surfactant activity was correlated to increased neutrophilic airway inflammation, but not to lung function.
Paul Karl +6 more
doaj +1 more source
Icequakes coupled with surface displacements for predicting glacier break-off
, 2010 A hanging glacier at the east face of Weisshorn (Switzerland) broke off in 2005. We were able to monitor and measure surface motion and icequake activity for 25 days up to three days prior to the break-off.
Allen +13 more
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
, 2010 We previously attempted to ascertain why the Li I 6708 line-strengths of Sun-like stars differ so significantly despite the superficial similarities of stellar parameters.
Ando, H. +4 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2009 We analyze the surface structure of the planet host star CoRoT-2a using a consistent model for both the `global' (i.e., rotationally modulated) lightcurve and the transit lightcurves, using data provided by the CoRoT mission.
Czesla, S. +3 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Space Place: Mapping the Watery Hills and Dales [PDF]
, 2001 This classroom activity explains how the Global Positioning System (GPS) satellites work to provide precise location information to positions on the ground, as well as to other satellites whose job is to map the surface of Earth.
core