Results 61 to 70 of about 682,225 (309)

Bacteria-Targeted Clindamycin Loaded Polymeric Nanoparticles: Effect of Surface Charge on Nanoparticle Adhesion to MRSA, Antibacterial Activity, and Wound Healing

Pharmaceutics, 2019
Adhesion of nanoparticles (NPs) to the bacterial cell wall by modifying their physicochemical properties can improve the antibacterial activity of antibiotic. In this study, we prepared positively charged clindamycin-loaded poly (lactic-co-glycolic acid)-
Nurhasni Hasan, Jiafu Cao, Juho Lee, Shwe Phyu Hlaing, Murtada A. Oshi, Muhammad Naeem, Min-Hyo Ki, Bok Luel Lee, Yunjin Jung, Jin-Wook Yoo   +9 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Salting the charged surface: pH and salt dependence of protein G B1 stability. [PDF]

, 2006
This study shows significant effects of protein surface charges on stability and these effects are not eliminated by salt screening. The stability for a variant of protein G B1 domain was studied in the pH-range of 1.5-11 at low, 0.15 M, and 2 M salt ...
Xue, Wei-Feng, Linse, Sara,, Bauer, Mikael C., Szczepankiewicz, Olga, Bauer, Mikael,, Lindman, Stina, Wei-Feng Xue, Xue, Wei-Feng,, Nilsson, Hanna,, Szczepankiewicz, Olga,, Stina Lindman, Olga Szczepankiewicz, Mikael C. Bauer, Hanna Nilsson, Lindman, Stina,, Nilsson, Hanna, Bauer, Mikael, Sara Linse, Linse, Sara, Lund University.   +19 more
core   +1 more source

Probing the surface charge of condensates using microelectrophoresis

, 2023
Biomolecular condensates play an important role in cellular organization. Coacervates are commonly used as model systems that mimic the physiochemical properties of biomolecular condensates, and are simultaneously studied as protocell models. The surface
Evan, Spruijt, Brent, Visser, Merlijn, van Haren   +2 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Space charge dynamics in low density polyethylene under dc electric fields

, 2007
In this paper space charge dynamics in low-density polyethylene (LDPE) under different dc electric fields, ranging from 25 kV/mm to 125 kV/mm, have been investigated using the pulsed electroacoustic (PEA) technique. Bipolar space charges have been formed
Xu, Zhiqiang, Chen, George
core   +1 more source

Space Charge Formation in Epoxy Resin Including Various Nanofillers [PDF]

, 2008
It has been widely anticipated that the combination of recent advances in nanocomposites technology with traditional and novel resin systems may create materials with enhanced electrical, thermal and mechanical properties.
Hajiyiannis, Alexis, Chao Zhang, Zhang, Chao, Gary Stevens, Alexis Hajiyiannis, George Chen, Stevens, Gary, Chen, George   +7 more
core   +1 more source

Antigen/adjuvant‐free liposome induces adjuvant effects for enhancing cancer immunotherapy

Exploration
Cancer vaccines are promising to treat malignancy by delivering antigens and adjuvants to elicit host immunity. Beyond aluminum adjuvants, liposomes show efficient adjuvant effects through regulating the accumulation, internalization and release of ...
Qianqian Guo, Xiaoxuan Xu, Xiaojiang Lai, Jialin Duan, Dan Yan, Dangge Wang   +5 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source