Results 101 to 110 of about 887,698 (266)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The Interplay of Surface Composition, Mineralogy, and Physical Conditions That Affect the Surface Release Processes and Particle Environment of Mercury

The Planetary Science Journal
Mercury has a very tenuous atmosphere starting at the surface, which is referred to as a surface-bound exosphere, where there are no collisions between exospheric particles.
Peter Wurz, Noah Jäggi, André Galli, Audrey Vorburger, Deborah Domingue, Paul S. Szabo, Johannes Benkhoff, Océane Barraud, Daniel Wolf Savin   +8 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A hybrid additive manufacturing platform to create bulk and surface composition gradients on scaffolds for tissue regeneration. [PDF]

Nat Commun, 2021
Sinha R, Cámara-Torres M, Scopece P, Verga Falzacappa E, Patelli A, Moroni L, Mota C.   +6 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Surface nanostructuring of titanium alloy dental screws by 10 keV Ar+ irradiation

Results in Surfaces and Interfaces
The influence of 10 keV Ar+ ion irradiation on the surface topography of Ti–6Al–4V dental screws was investigated. The surface facing the ion beam became uniformly covered with nanoprotrusions, the size of which increased with the ion fluence.
A.E. Ieshkin, K.F. Minnebaev, D.S. Kireev, A.A. Tatarintsev   +3 more
doaj   +1 more source

On the Origin of Reduced Cytotoxicity of Germanium-Doped Diamond-Like Carbon: Role of Top Surface Composition and Bonding. [PDF]

Nanomaterials (Basel), 2021
Zemek J, Jiricek P, Houdkova J, Ledinsky M, Jelinek M, Kocourek T.   +5 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

JWST Thermal Emission of the Terrestrial Exoplanet GJ 1132b

The Astrophysical Journal Letters
We present thermal emission measurements of GJ 1132b spanning 5–12 μ m obtained with the Mid-Infrared Instrument Low-Resolution Spectrometer on the James Webb Space Telescope.
Qiao Xue, Jacob L. Bean, Michael Zhang, Alexandra Mahajan, Jegug Ih, Jason D. Eastman, Jonathan Lunine, Megan Weiner Mansfield, Brandon Park Coy, Eliza M.-R. Kempton, Daniel Koll, Edwin Kite   +11 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source