Results 111 to 120 of about 1,097,727 (354)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Отримання виливків із диференційованими властивостями поверхні

open access: yesНаукові вісті Національного технічного університету України "Київський політехнічний інститут", 2017
Проблематика. Під час експлуатації литих деталей машин і механізмів найінтенсивнішим зовнішнім впливам піддаються поверхневі шари, тому саме їх структура й властивості визначають працездатність виробів у цілому.
Alexander G. Kovalchuk   +2 more
doaj   +1 more source

Surface modification of bioceramics: chemically enhanced laser surface microstructuring of hydroxyapatite

open access: yes, 2008
PhDBioceramics have been developed for implants to repair damaged tissues of the human musculo-skeletal system. The clinical success of a bioceramic implant depends largely on the chemical response at the implant interface in addition to the ...
Norton, Judy A. M., Norton, Judy A M
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Stable carbon and radiocarbon isotope compositions of particle size fractions to determine origins of sedimentary organic matter in an estuary [PDF]

open access: yes, 2002
Stable and radioactive carbon isotopic compositions of particle size fractions of a surface sediment from the Ems-Dollard estuary vary considerably with particle size. The organic material in the fine fractions (
Megens, L.,   +7 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Estimate of Water and Hydroxyl Abundance on Asteroid (16) Psyche from JWST Data

open access: yesThe Planetary Science Journal
Our understanding of solar system evolution is closely tied to interpretations of asteroid composition, particularly the M-class asteroids. These asteroids were initially thought to be the exposed cores of differentiated planetesimals, a hypothesis based
Stephanie G. Jarmak   +12 more
doaj   +1 more source

The role of bacterial surface polymers in the adhesion of freshwater bacteria to solid surfaces [PDF]

open access: yes
In the study of the mechanism of non-specific permanent adhesion of bacteria at the solid-liquid interface a number of alternative approaches have been used.
Pringle, James Howard
core  

The application of pulsed plasmas towards controlled surface functionalisation [PDF]

open access: yes, 1998
Pulsed plasmas were investigated as a means of controlling the composition of the surfaces generated via plasma polymerisation. A variety of precursors were studied under a range of plasma conditions using both continuous wave and pulsed plasmas. Surface
Hynes, Alan
core  

The influence of laser glazing on morphology, composition and microhardness of thermal sprayed Ni-WC coatings

open access: yes, 2022
S.128-135Ni-based, thermally sprayed coatings have many commercial applications for wear and corrosion resistance at low and moderate temperatures. The performance of Ni-based coatings can be improved further by adding hard precipitates such as carbides ...
Kumari, S., Khanna, A.S., Gasser, A.
core  

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