Results 141 to 150 of about 2,901,641 (329)
Global Distribution of the Key Species on the Surface of Europa
The Astrophysical JournalThe icy surface of Europa is continuously bombarded by ions and electrons from Jupiter’s magnetosphere. The bombardment of the particles dissociates water molecules on the surface of Europa and introduces impurities to the icy surface.
Jiazheng Li +3 more
doaj +1 more source
Regulation of depth and composition of airway surface liquid [PDF]
, 1997 JH Widdicombe +3 more
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Nanotechnology, Science and Applications, 2017 Tehila Nahum,1 Hanna Dodiuk,2 Samuel Kenig,2 Artee Panwar,1 Carol Barry,1 Joey Mead,1 1Department of Plastics Engineering, University of Massachusetts Lowell, Lowell, MA, USA; 2Department of Polymers and Plastics Engineering, Shenkar College of ...
Nahum T +5 more
doaj
Spatiotemporal Variation of Surface Urban Heat Islands in Relation to Land Cover Composition and Configuration: A Multi-Scale Case Study of Xi’an, China [PDF]
, 2020 Linlin Lu +5 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Pwyll and Manannán Craters as a Laboratory for Constraining Irradiation Timescales on Europa
The Planetary Science JournalWe examine high-spatial-resolution Galileo/Near-Infrared Mapping Spectrometer observations of the young (∼1 My–∼20 My) impact features, Pwyll and Manannán craters, on Europa’s trailing hemisphere in an effort to constrain irradiation timescales.
M. Ryleigh Davis, Michael E. Brown
doaj +1 more source