Results 141 to 150 of about 7,823,830 (309)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The Interplay of Surface Composition, Mineralogy, and Physical Conditions That Affect the Surface Release Processes and Particle Environment of Mercury

The Planetary Science Journal
Mercury has a very tenuous atmosphere starting at the surface, which is referred to as a surface-bound exosphere, where there are no collisions between exospheric particles.
Peter Wurz, Noah Jäggi, André Galli, Audrey Vorburger, Deborah Domingue, Paul S. Szabo, Johannes Benkhoff, Océane Barraud, Daniel Wolf Savin   +8 more
doaj   +1 more source

Journal of Advanced Composition

, 1981
The Journal of Advanced Composition contains a collection of papers regarding writing and rhetoric: "The JAC is a forum for theory, research and pedagogy regarding (1) those writing courses beyond the freshman courses, excluding technical and creative ...
Lally, Tim D. P., Association of Teachers of Advanced Composition (U.S.)   +1 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A hybrid additive manufacturing platform to create bulk and surface composition gradients on scaffolds for tissue regeneration. [PDF]

Nat Commun, 2021
Sinha R, Cámara-Torres M, Scopece P, Verga Falzacappa E, Patelli A, Moroni L, Mota C.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

JWST Thermal Emission of the Terrestrial Exoplanet GJ 1132b

The Astrophysical Journal Letters
We present thermal emission measurements of GJ 1132b spanning 5–12 μ m obtained with the Mid-Infrared Instrument Low-Resolution Spectrometer on the James Webb Space Telescope.
Qiao Xue, Jacob L. Bean, Michael Zhang, Alexandra Mahajan, Jegug Ih, Jason D. Eastman, Jonathan Lunine, Megan Weiner Mansfield, Brandon Park Coy, Eliza M.-R. Kempton, Daniel Koll, Edwin Kite   +11 more
doaj   +1 more source

Surface nanostructuring of titanium alloy dental screws by 10 keV Ar+ irradiation

Results in Surfaces and Interfaces
The influence of 10 keV Ar+ ion irradiation on the surface topography of Ti–6Al–4V dental screws was investigated. The surface facing the ion beam became uniformly covered with nanoprotrusions, the size of which increased with the ion fluence.
A.E. Ieshkin, K.F. Minnebaev, D.S. Kireev, A.A. Tatarintsev   +3 more
doaj   +1 more source

On the Origin of Reduced Cytotoxicity of Germanium-Doped Diamond-Like Carbon: Role of Top Surface Composition and Bonding. [PDF]

Nanomaterials (Basel), 2021
Zemek J, Jiricek P, Houdkova J, Ledinsky M, Jelinek M, Kocourek T.   +5 more
europepmc   +1 more source