Results 131 to 140 of about 4,863,941 (314)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanism of secondary currents in open channel flows
, 2012 This paper describes the conditions for initiation and maintenance of secondary currents in open channel flows. By analyzing the Reynolds equation in the wall-normal and wall-tangent directions, this study reveals that, like other types of vortices, the ...
Tan, Soon Keat +2 more
core +1 more source
Frontiers in Marine ScienceHigh-resolution hydrodynamic data are essential for coastal and estuarine management. However, traditional downscaling methods based on numerical modeling remain computationally expensive, limiting their applicability for long-term hindcasts and ...
Mirko Rupani +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Measuring ocean currents : tools, technologies, and data /
Measuring Ocean Currents: Tools, Technologies, and Data covers all major aspects of ocean current measurements in view of the implications of ocean currents on changing climate, increasing pollution levels, and offshore engineering activities.
Joseph, Antony,author.
core
ANALYSIS OF SURFACE-ANTIGENS AND ION CURRENTS BY FLOW-CYTOMETRY
, 1991 Frey J. ANALYSIS OF SURFACE-ANTIGENS AND ION CURRENTS BY FLOW-CYTOMETRY. BIOLOGICAL CHEMISTRY HOPPE-SEYLER.
Frey, Jürgen
core
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Investigation on the dynamics of gravity-driven coastal currents [PDF]
Numerical simulations of buoyant, gravity-driven coastal plumes are summarized and compared to the inviscid geostrophic theory of Thomas & Linden (2007) and to laboratory studies for plumes owing along a vertical-wall coastline (those of Thomas ...
Gregorio, S. O. (Sandy O.)
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source