Results 121 to 130 of about 4,863,941 (314)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Observations of sea surface temperatures and ocean currents from Nimbus 2 [PDF]
, 1967 Sea surface temperatures and ocean currents observed from Nimbus 2 satellite with infrared ...
Warnecke, G. +2 more
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Surface currents in the Alderney Race from high-frequency radar measurements and three-dimensional modelling. [PDF]
Philos Trans A Math Phys Eng Sci, 2020 Lopez G +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Superconductors in alternating fields [PDF]
After a general introduction to the fundamentals of superconductivity, the concept of the critical state is introduced and its application to alternating field conditions discussed. A comprehensive review of the a.c.
Linford, Rodney Martin Forbes
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Ocean Surface Currents Glossary
This glossary provides short definitions of the oceanographic jargon used to describe ocean surface currents. It is designed to accompany the website "Ocean Surface Currents", a reference that provides information on surface currents in the world's ...
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Sea Surface Height and geostrophic currents during the DIAPICNA cruise.
, 2016 Station locations (open circles) overlaid on AVISO altimetry-derived geostrophic currents centered between 26/07/2011 and 01/08/2011, with color scale indicating the Sea Surface Height (SSH) in m.
Clara Magalhães Loureiro (2558374) +12 more
core +1 more source