Results 111 to 120 of about 654,094 (303)

On closed currents invariant by holomorphic foliations, I

, 2012
We consider closed positive currents invariant by a singular holomorphic foliation on an algebraic surface.
Rebelo, Julio C.
core   +1 more source

Aging Studies for the Large Honeycomb Drift Tube System of the Outer Tracker of HERA-B

, 2003
The HERA-B Outer Tracker consists of drift tubes folded from polycarbonate foil and is operated with Ar/CF4/CO2 as drift gas. The detector has to stand radiation levels which are similar to LHC conditions.
Albrecht, H, Bauer, T S, Beck, M, Belkov, A, Berkhan, K, Bohm, G, Bruinsma, M, Buran, T, Capeans, M, Chamanina, J, Chen, BX, Deckers, H, Dehmelt, K, Dong, X, Eckmann, R, Emelianov, D, Fourletov, S, Golutvin, I, Hoepfner, Kerstin, Hohlmann, M, Hulsbergen, W, Jia, Y, Jiang, C, Kapitza, H, Karabekyan, S, Ke, Z, Kiryushin, Y, Kolanoski, H, Korpar, S, Krizan, P, Krucker, D, Lanyov, A, Liu, Y Q, Lohse, T, Loke, R, Mankel, R, Medin, G, Michel, E, Moshkin, A, Ni, J, Nowak, S, Ouchrif, M, Padilla, C, Pose, D, Ressing, D, Saveliev, V, Schmidt, B, Schmidt-Parzefall, W, Schreiner, A, Schwanke, U, Schwarz, Andreas S, Siccama, I, Solunin, S, Somov, S, Souvorov, V, Spiridonov, A, Staric, M, Stegmann, C, Steinkamp, O, Tesch, N, Tsakov, I, Uwer, U, Vassiliev, S, Vukotic, I, Walter, M, Wang, J J, Wang, Y M, Wurth, R, Yang, J, Zheng, Z, Zhu, Z, Zimmerman, R   +71 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Improving Coastal Circulation Using HF‐Radar Surface Currents

Earth and Space Science
In an attempt to improve the model‐derived coastal circulation around India, we explore three different frameworks to assimilate surface currents from HF‐Radars into an ocean model for the Indian Ocean.
Vinod Daiya, Balaji Baduru, Jagdish Prajapati, Biswamoy Paul, Arya Paul   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Calculation of wind-driven surface currents in the North Atlantic Ocean [PDF]

Calculations to simulate the wind driven near surface currents of the North Atlantic Ocean are described. The primitive equations were integrated on a finite difference grid with a horizontal resolution of 2.5 deg in longitude and latitude.
Rees, T. H., Turner, R. E.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source