Results 81 to 90 of about 38,626 (306)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

¹⁰Be surface exposure dating of the deglaciation of northernmost Norway and Finland

Boreas, 2020
During the Last Glacial Maximum, the coast of Finnmark county, northern Norway, was covered by the Scandinavian Ice Sheet (SIS), which coalesced with the Barents Sea Ice Sheet (BSIS) off the coast. The region is thus important for our understanding of the dynamic interactions between the BSIS and the SIS, yet it remains one of the least dated regions ...
Johanna Anjar, Naki Akçar, Thomas Lakeman, Eiliv A. Larsen, Martin Seiler   +4 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Amino acid racemization dating: Method development using African ostrich (Struthio camelus) eggshell [PDF]

, 2013
Ostrich eggshell (OES) is ubiquitous in archaeological sites in Africa and is a favoured substrate for amino acid racemisation (AAR) geochronology, yielding consistent results and thought to approximate a closed system with respect to protein diagenesis.
Crisp, Molly Katherine
core  

Recognition of non-Milankovitch sea-level highstands at 185 and 343 thousand years ago from U-Th dating of Bahamas sediment [PDF]

, 2006
Thirty-one new bulk-sediment U-Th dates are presented, together with an improved δO stratigraphy, for ODP Site 1008A on the slopes of the Bahamas Banks. These ages supplement and extend those from previous studies and provide constraints on the timing of
Henderson, Gideon M., Cox, K, Thomas, A.L., Robinson, L.F., Henderson, Gideon, Thomas, Alex L., Robinson, LF, Henderson, GM, Henderson, G.M., Cox, Katharine, Cox, K., Thomas, AL, Robinson, Laura F.   +12 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Effect of related parameters on exposure age and erosion rate obtained via rock surface luminescence dating

He jishu
BackgroundRock surface luminescence dating has developed rapidly in the past decade. It has been widely used to obtain exposure ages and erosion rates of various rocks in archaeology, geology, and geography, such as stone artifacts, glacier bedrock ...
LUO Ming, GONG Zhijun, GUO Fusheng, PENG Huaming   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

An Icelandic freshwater radiocarbon reservoir effect: implications for lacustrine ¹⁴C chronologies [PDF]

, 2011
A freshwater radiocarbon (¹⁴C) reservoir effect (FRE) is a ¹⁴C age offset between the atmospheric and freshwater carbon reservoirs.
Einarsson, A., M.J. Church, McGovern, TH, Hastie, Helen, McGovern, T.H., Cook, G., Church, M.J., Church, MJ, P.L. Ascough, Cook, GT, E. Dunbar, A.J. Dugmore, Dugmore, AJ, Dunbar, E, T.H. McGovern, Dugmore, A.J., H. Hastie, Á. Einarsson, Ascough, P., Hastie, H, G.T. Cook, Einarsson, Á, Ascough, PL, Dunbar, E.   +23 more
core   +1 more source