Results 61 to 70 of about 37,381 (262)

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Assessment of road pavement conditions using Surface Distress Index (SDI) and Pavement Condition Index (PCI) methods

IOP Conference Series: Earth and Environmental Science
Abstract Road pavement is an important element in transportation infrastructure that affects the comfort and safety of road users. It is important to carry out regular assessments of the condition of the road pavement. This study aims to evaluate the condition of the road pavement using the Surface Distress Index (SDI) and Pavement ...
Putu Hermawati, N P A S Putri
openaire   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Kolaborasi Metode Empiris dan Mekanistik-Empiris Guna Identifikasi dan Evaluasi Kinerja Perkerasan Jalan

Teras Jurnal: Jurnal Teknik Sipil
Abstrak   Kerusakan jalan yang tidak teratasi dengan baik dapat mengganggu aktivitas ekonomi dan mobilitas masyarakat, sehingga kondisi ini harus segera diantisipasi dengan berupa proses identifikasi dan evaluasi terhadap kinerja perkerasan baik itu ...
Dede Kurniawan, Muhamad Abdul Hadi
doaj   +1 more source

Adhesion at asphalt-aggregate interface through surface energy

Transportes, 2020
One of the most common problems pavements have is the loss of adhesion and cohesion due to moisture damage.  Tropical countries and rainy seasons are some of the causes for this type of distress on roads.
Ana Sofia Figueroa Infante, Fredy Reyes Lizcano, Néstor Cely Leal   +2 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Analisis Kerusakan Jalan Metode SDI Taluk Kuantan - Batas Provinsi Sumatera Barat

Siklus: Jurnal Teknik Sipil, 2020
Jalan Lintas Taluk Kuantan Batas Provinsi Sumatera Barat ini berada di Kecamatan Kuantan Mudik, Kabupaten Kuantan Singingi (lintas tengah), merupakan jalan nasional yang menghubungkan Provinsi Riau, Jambi dan Sumatera Barat, yang terdapat kerusakan pada ...
Gesvi Aptarila, Fadrizal Lubis, Alfian Saleh   +2 more
doaj   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

A Disaggregation Strategy for Nanopesticide Fabrication: Investigating the Impact of Nanosizing on Pesticide Biointeractions

Advanced Science, EarlyView.
To explore the impact of nanosizing on pesticide biointeractions, a 7‐nm (average) emamectin benzoate nanopesticide without nanocarriers or surfactants is fabricated via HOAc‐mediated disaggregation. Nanosizing enhances bioactivity against Megalurothrips usitatus and Meloidogyne enterolobii and improves plant penetration.
Jiaqi Wei, Jianxin Feng, Huiting Zhu, Kunzhong Lin, Chenhan Liu, Lin Li, Zhuoyan Xiao, Daihao Huang, Rong Liu, Huipeng Pan, Lingda Zeng, Hanhong Xu   +11 more
wiley   +1 more source

ANALYSIS OF ROAD DAMAGE BASED ON THE BINA MARGA METHOD, SURFACE DISTRESS INDEX (SDI), AND PKRMS V.1.4.5 ON TLOGOWUNGU ROAD, PATI

Journal Innovation of Civil Engineering
This study aims to identify the types of road damage on Tlogowungu Road, Pati, within the section from Sta 0+000 to Sta 1+500. The study evaluates the road conditions and determines appropriate maintenance solutions using the Bina Marga 1990 method ...
Siti Nurhalisah, Kurnia Hadi Putra, Theresia Maria Chandra Agusdini   +2 more
doaj   +1 more source