Results 81 to 90 of about 37,381 (262)

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Dual Model for International Roughness Index Classification and Prediction

Infrastructures
Existing models for predicting the international roughness index (IRI) of a road surface often lack adaptability, struggling to accurately reflect variations in climate, traffic, and pavement distresses—factors critical for effective and sustainable ...
Noelia Molinero-Pérez, Laura Montalbán-Domingo, Amalia Sanz-Benlloch, Tatiana García-Segura   +3 more
doaj   +1 more source

Analisis Kerusakan Jalan Udara Kabupaten Karo dengan Metode Surface Distress Index (SDI)

Syntax Literate ; Jurnal Ilmiah Indonesia
Jalan merupakan prasarana penting dalam mendukung laju perekonomian serta memiliki peran besar dalam kemajuan dan perkembangan suatu daerah. Kondisi jalan yang mengalami kerusakan akan berdampak langsung terhadap aktivitas masyarakat. Di Kabupaten Karo, khususnya di Kecamatan Berastagi, telah terjadi kerusakan pada perkerasan jalan yang mengakibatkan ...
Fenny Novita Meysabed Sianturi, Palghe Tobing, Desnitha Cristina Br Ketaren   +2 more
openaire   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, EarlyView.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source

Study on Distress Characteristics of Asphalt Pavement Under Heavy-Duty Traffic Based on Lightweight Road Inspection Equipment

Infrastructures
This study, based on the maintenance engineering of regular national and provincial highways in Shanxi Province, aims to achieve refined maintenance of aging asphalt pavements under heavy-duty traffic conditions. Lightweight inspection equipment was used
Hong Zhang, Yuanshuai Dong, Yun Hou, Xinlong Tong, Xiangjun Cheng, Keming Di   +5 more
doaj   +1 more source

GIS-Based Evaluation of Flexible Pavement Condition in Kediri Using Surface Distress Index Method

AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment)
Road infrastructure is a vital component in supporting regional economic growth and social connectivity, including the Gayam–Sidorejo road section in Kediri District, which functions as a primary collector road. This study aims to identify pavement distress along the 8.383 km Gayam–Sidorejo road segment, determine its functional condition using the ...
Maulana Zidan Dwi Cahya, null Hendrata Wibisana, Aulia Dewi Fatikasari   +2 more
openaire   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Surface Distress Index Updates to Improve Crack Damage Evaluation [PDF]

Proceedings of the 11th Asia Pacific Transportation and the Environment Conference (APTE 2018), 2019
Djoko Purwanto, null Supriyono, Bagus Setiadji   +2 more
openaire   +1 more source