Results 81 to 90 of about 37,520 (301)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Kolaborasi Metode Empiris dan Mekanistik-Empiris Guna Identifikasi dan Evaluasi Kinerja Perkerasan Jalan

Teras Jurnal: Jurnal Teknik Sipil
Abstrak   Kerusakan jalan yang tidak teratasi dengan baik dapat mengganggu aktivitas ekonomi dan mobilitas masyarakat, sehingga kondisi ini harus segera diantisipasi dengan berupa proses identifikasi dan evaluasi terhadap kinerja perkerasan baik itu ...
Dede Kurniawan, Muhamad Abdul Hadi
doaj   +1 more source

Analysis Of Road Damage Repair Using SDI (Surface Distress Index) Method

Journal of Scientific Research, Education, and Technology (JSRET)
Road damage is something that must be addressed immediately because roads play an important role such as connecting remote areas to economic centers, connecting public services, providing mobility for humans or goods, and other social activities that cross the KS Tubun - Merpati road, Tegal City.
Muhammad Alif Ridwan Ridwan, M. Daffa Izzuddin, Raditya Faris Nailulloh, Dani Fitria Brilianti   +3 more
openaire   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Comparison of Pavement Performance Models for Urban Road Management System

The Baltic Journal of Road and Bridge Engineering, 2020
The key factors for effective pavement management system (PMS) are timely preservation and rehabilitation activities, which provide benefit in terms of drivers’ safety, comfort, budget and impact on the environment.
Igoris Kravcovas, Audrius Vaitkus, Rita Kleizienė   +2 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

ANALYSIS OF ROAD DAMAGE BASED ON THE BINA MARGA METHOD, SURFACE DISTRESS INDEX (SDI), AND PKRMS V.1.4.5 ON TLOGOWUNGU ROAD, PATI

Journal Innovation of Civil Engineering
This study aims to identify the types of road damage on Tlogowungu Road, Pati, within the section from Sta 0+000 to Sta 1+500. The study evaluates the road conditions and determines appropriate maintenance solutions using the Bina Marga 1990 method ...
Siti Nurhalisah, Kurnia Hadi Putra, Theresia Maria Chandra Agusdini   +2 more
doaj   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Surfactant therapy in late preterm infants

Journal of Pediatric and Neonatal Individualized Medicine, 2013
Late preterm (LPT) neonates are at a high risk for respiratory distress soon after birth due to respiratory distress syndrome (RDS), transient tachypnea of the newborn, persistent pulmonary hypertension, and pneumonia along with an increased need for ...
Murat Yurdakök
doaj   +1 more source