Results 91 to 100 of about 37,381 (262)

Analisa Pemeliharaan Jalan Berkala Kota Jambi dengan Metode Sdi (Surface Distress Index)

Jurnal Civronlit Unbari
Roads are land transportation infrastructure which includes all parts of the road. Good road conditions really support the smooth running of the economy in an area so that road maintenance is very important so that the smooth running of the economy is not disrupted by poor road infrastructure.
Suman Jaya Dinata Purba, Fakhrul Rozi Yamali, Wari Dony   +2 more
openaire   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Analysis of Road Damage Levels Using the Surface Distress Index Method and Handling Cracked Roads

ASTONJADRO
Analysis of the Level of Road Damage Using the Surface Distress Index Method and Evaluation and Handling of Cracked Roads (Case Study: Jalan Ciherang Cutak-Jalan Suka Mulya, Ciomas District, Bogor Regency. The existence of roads is very necessary to support the rate of agricultural and other economic growth, considering the important benefits So the ...
Haldiana Haldiana, Muhamad Nanang Prayudyanto, Rulhendri Rulhendri   +2 more
openaire   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Young children's perspectives of time: New directions for co‐constructing understandings of quality in ECEC

British Educational Research Journal, EarlyView., 2023
Abstract Children's relationship with time in preschools is an under‐researched area. Young children rarely know how to measure time using a clock, but their experiences of time may contribute to understanding children's well‐being and debates about quality in preschools.
Kristín Dýrfjörð, Anna Magnea Hreinsdóttir, Adrijana Visnjic‐Jevtic, Alison Clark   +3 more
wiley   +1 more source

Leveraging Maintenance Management Techniques to Evaluate Pavement Condition Index: Central Iraq Highway System

Journal of Engineering and Sustainable Development
The objective of this paper is to evaluate the maintenance strategies applied to the Latifiya-Musayib highway section to improve the pavement condition that significantly deteriorated due to military operations during and after the third Gulf War.
Ahmed Aljubory , Teba Tariq Khaled, Ali Jabbar Kadhim , Mohd Fazaulnizam Bin Shamsudin, Andrew Minto , Rwayda Kh. S. Al-Hamd   +5 more
doaj   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Ambient temperature, rainfall, and adverse maternal and child health outcomes in Nigeria: evidence from a national cross-sectional study

Frontiers in Public Health
BackgroundClimate change increasingly threatens public health in West Africa, with pregnant women and young children particularly vulnerable. Despite Nigeria’s high exposure to climate risks, epidemiological evidence linking temperature and rainfall to ...
Asri Maharani, Tung Le, Tung Le, Jahanara Miah, Zahra Mulla, Amy Blakemore, Deborah Aluh, Deborah Aluh, Deborah Aluh, John Jemisenia, John Jemisenia, Ngozi Idemili-Aronu, Ngozi Idemili-Aronu, Echezona Edozie Ezeanolue, Echezona Edozie Ezeanolue, Martie van Tongeren, Rathi Ravindrarajah   +16 more
doaj   +1 more source

Identifikasi dan Analisis Kerusakan Jalan Menggunakan Metode Pavement Condition Index (PCI) dan Surface Distress Index (SDI)

Empiricism Journal
Jalan Milir – Dayakan memiliki nomor ruas 022 dengan Panjang ruas jalan di 3,6 km sesuai dalam Surat Keputusan Gubernur Daerah Istimewa Yogyakarta Nomor 124/KEP/2023 Tentang Penetapan Ruas Jalan Menurut Statusnya sebagai Jalan Provinsi dengan lebar ruas 6,7 meter dan tipe jalan 2/2 UD dengan kelas jalan III.
Widarto Sutrisno, Detha Sekar Langit Wahyu Gutama, July Khusnul Qotimah, Kurniawan Kurniawan   +3 more
openaire   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source