Results 71 to 80 of about 37,381 (262)

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Evaluasi Kondisi Permukaan Jalan Dengan Metode Road Condition Index (RCI) dan Surface Distress Index (SDI)

Jurnal Ilmiah Ecosystem
Penelitian ini bertujuan untuk nengevaluasi kondisi Permukaan Jalan Pada Ruas Jalan Pelabuhan Munte, Desa Rampoang, Kecamatan Tana lili, Kabupaten Luwu Utara dengan Mengunakan Dua metode yaitu Road Condition Index (RCI) dan Surface Distress Index (SDI). Hasil penelitian menunjukkan bahwa nilai rata-rata RCI pada ruas jalan sepanjang 1 km adalah sebesar
Nurul Asya Sunardi, Rakhmawati Natsir, Muhammad Fikri   +2 more
openaire   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

A case study on predicting asphalt pavement distress using advanced machine learning techniques and road surface inspection data

Case Studies in Construction Materials
This study develops robust machine learning models to predict pavement distress using high-resolution road surface scan data. The dataset includes 4685 samples representing various pavement conditions across different locations.
Abolfazl Yazdi, Mohammad Hosein Dehnad
doaj   +1 more source

Surfactant therapy in late preterm infants

Journal of Pediatric and Neonatal Individualized Medicine, 2013
Late preterm (LPT) neonates are at a high risk for respiratory distress soon after birth due to respiratory distress syndrome (RDS), transient tachypnea of the newborn, persistent pulmonary hypertension, and pneumonia along with an increased need for ...
Murat Yurdakök
doaj   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

The effects of anxiety and total body surface area burn on functional limitations: a cross-sectional study

Rehman Journal of Health Sciences
Background: Burn is one of the most traumatic injuries globally. The leading cause of the burn is fire, gas cylinder blast, electric shock and chemical burn.
Syed Hassnain Shah, Laiba Malik, Amna Khan, Hina Azam, Munazza Shah, Shakir Ullah   +5 more
doaj   +1 more source

ANALISIS DAMPAK REFOCUSING ANGGARAN TERHADAP KONDISI JALAN DENGAN METODE SURFACE DISTRESS INDEX (SDI)

INFOMANPRO, 2023
Pemerintah Indonesia telah melakukan berbagai upaya untuk menangani penyakit menular yang disebabkan oleh virus SARS-CoV-2 ini, salah satunya melalui Instruksi Presiden Republik Indonesia No. 4 tahun 2020 tentang Refocussing Kegiatan, Realokasi Anggaran, Serta Pengadaan Barang dan Jasa Dalam Rangka Percepatan Penanganan Corona Virus Disease 2019 (Covid-
openaire   +1 more source