Results 111 to 120 of about 37,520 (301)

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Analisis Kerusakan Jalan Pada Ruas Jalan Jalur Lingkar Barat Kepanjen – Jalan Raya Gunung Kawi (JALIBAR) Kabupaten Malang dengan Metode Surface Distress Index (SDI)

, 2023
Jalan merupakan penunjang mobilisasi orang dan barang untuk berpindah dari satu tempat ke tempat lain. Unsur dan bagian terpenting dari suatu ruas jalan merupakan perkerasan jalan karena memiliki fungsi untuk menjaga kelancaran transportasi darat dari ...
Ashfa, Mukhamad Masfaq
core  

Analisa Penilaian Kondisi Jalan Raya Dengan Metode Surface Distress Index (SDI) Dan Present Serviceability Index (PSI) Studi Kasus : Duri Kecamatan Mandau [PDF]

, 2021
Good road conditions will facilitate the mobility of the population in economic relations and other social activities. Therefore, it is necessary to keep the condition in good condition with maintenance according to road conditions. So it is necessary to
Anugrah, Dewi Asri
core  

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Leveraging Maintenance Management Techniques to Evaluate Pavement Condition Index: Central Iraq Highway System

Journal of Engineering and Sustainable Development
The objective of this paper is to evaluate the maintenance strategies applied to the Latifiya-Musayib highway section to improve the pavement condition that significantly deteriorated due to military operations during and after the third Gulf War.
Ahmed Aljubory , Teba Tariq Khaled, Ali Jabbar Kadhim , Mohd Fazaulnizam Bin Shamsudin, Andrew Minto , Rwayda Kh. S. Al-Hamd   +5 more
doaj   +1 more source

Surface Distress Index Updates to Improve Crack Damage Evaluation [PDF]

Proceedings of the 11th Asia Pacific Transportation and the Environment Conference (APTE 2018), 2019
Djoko Purwanto, null Supriyono, Bagus Setiadji   +2 more
openaire   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Comparative Analysis of Responses of Land Surface Temperature to Long-Term Land Use/Cover Changes between a Coastal and Inland City: A Case of Freetown and Bo Town in Sierra Leone

Remote Sensing, 2018
Urban growth and its associated expansion of built-up areas are expected to continue through to the twenty second century and at a faster pace in developing countries. This has the potential to increase thermal discomfort and heat-related distress. There
Musa Tarawally, Wenbo Xu, Weiming Hou, Terence Darlington Mushore   +3 more
doaj   +1 more source

EVALUASI TINGKAT KERUSAKAN JALAN MENGGUNAKAN METODE PAVEMENT CONDITION INDEX (PCI) DAN SURFACE DISTRESS INDEX (SDI) (Studi Kasus: Jalan Raya Simpang Dua, Kecamatan Simpang Dua, Kabupaten Ketapang)

Penelitian ini mengevaluasi kondisi kerusakan perkerasan jalan raya Simpang Dua, jalur strategis yang menghubungkan Kabupaten Ketapang dan Kabupaten Kayong Utara.
Widodo, Slamet, Lesyani, Agustinus Hendy, Azwansyah, Heri   +2 more
core   +1 more source