Results 111 to 120 of about 37,381 (262)

Classification of Urban Road Damage Levels Using Surface Distress Index Parameters and K-means Algorithm

Dinamika Rekayasa
Road damage is a significant problem in many countries, including Indonesia, and it can affect safety, transportation efficiency, and the quality of life of communities, especially on urban roads. This study aims to develop a data-based model using the K-Means algorithm to detect and classify the levels of urban road damage based on the Surface ...
Yogi Oktopianto, Antonius Antonius, Abdul Rochim   +2 more
openaire   +1 more source

Analysis of Road Damage Levels Using the SDI (Surface Distress Index) Method for Evaluation and Handling of Potholes

ASTONJADRO
Highways are land transportation infrastructure that is very important in facilitating economic relations activities. The method used is the SDI (Surface Distress Index) method. The purpose of this study is to identify the types of road damage, analyze the level of road damage using the SDI method and evaluate the SDI value and handling potholes.
Muhammad Nanang Prayudyanto, Rulhendri Rulhendri, Syaiful Syaiful, Riki Natanael Ramadan   +3 more
openaire   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

AI-Driven Pavement Condition Assessment from Dash-Cam Imagery: A Comparative Analysis of YOLOv8-Based PCI Estimation, Manual Inspections, and Automated PASER Ratings in Urban Networks

Infrastructures
This study presents an AI-enabled framework for automated pavement condition assessment in urban environments by integrating YOLOv8-based distress detection, computational Pavement Condition Index (PCI) estimation, and comparative validation against ...
Giulia Del Serrone, Giuseppe Loprencipe, Laura Moretti   +2 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

MetaboSense: An Integrated Quantum Dot‐Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In‐Line Monitoring of Lung Metabolism During Ex Vivo Perfusion

Advanced Science, EarlyView.
MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant, Pouyan Keshavarz Motamed, Thomas Borrillo, Lielle Ronen, Gabriel Siebiger, Guillermo Garza, Hesam Abouali, Md Fahim Al Fattah, Ines Jaber, Dayan Ban, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee, Andrew T. Sage, Mahla Poudineh   +14 more
wiley   +1 more source

Analisis Penilaian Kondisi Perkerasan Jalan Dengan Metode PCI (Pavement Condition Index), SDI (Surface Distress Index) dan IRI (International Roughness Index)

Syntax Idea
Jalan sangat penting bagi transportasi darat yang dapat memberikan pengaruh terhadap ekonomi, sosial, budaya maupun politik di suatu daerah, namun perkerasan jalan mengalami kerusakan dengan perkembangan penggunaan kenderaan serta beban yang berlebihan sehingga perlu adanya survei kondisi jalan. Penelitian dilakukan di jalan nasional Pulau Seram Barat,
La Hasrudin, Indra Maha
openaire   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Analysis of pedestrian walkability index in urban footpaths

Urban, Planning and Transport Research
This study delves into the analysis of pedestrian walkability on urban roads of India. Providing a safe environment for pedestrians in urban areas is difficult due to poor geometry of footpaths.
S. Rakshith, Archana M. R., V. Anjaneyappa   +2 more
doaj   +1 more source