Results 91 to 100 of about 94,167 (304)

Bile Duct Adenoma with Oncocytic Features

open access: yesCase Reports in Pathology, 2014
Bile duct adenomas are benign bile duct proliferations usually encountered as an incidental finding. Oncocytic bile duct neoplasms are rare and the majority are malignant.
E. J. Johannesen   +2 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

open access: yesAdvanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong   +5 more
wiley   +1 more source

Analysis on the Low Speed Performance of an Inward-Turning Multiduct Inlet for Turbine-Based Combined Cycle Engines

open access: yesInternational Journal of Aerospace Engineering, 2019
The multiduct inlet for turbine-based combined cycle engines receives a lot of attention on its aerodynamic performance. Aside of the most studied mode of transition processes, another significant severe issue regarding the aerodynamic performance of the
Chengxiang Zhu   +3 more
doaj   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

open access: yesAdvanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang   +10 more
wiley   +1 more source

A study of the turbulent wake of an airfoil in an air stream with a 90° curvature using hot-wire anemometry and large eddy simulation

open access: yes, 2008
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The broad aim of the work presented in this thesis is to investigate the wake of an airfoil under the combined effects of streamwise curvature and pressure ...
Farsimadan, Ehsaan
core  

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

open access: yesAdvanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu   +18 more
wiley   +1 more source

A rational approximation to the evolution of a free surface during fluid withdrawal through a point sink

open access: yes, 2010
The time varying flow in which fluid is withdrawn from a reservoir through a point sink of variable strength beneath a free surface is considered. Asymptotic techniques are used to derive an approximate solution to the flow that is valid at intermediate ...
Forbes, Lawrence K.   +4 more
core  

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

open access: yesAdvanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li   +6 more
wiley   +1 more source

Statistical Analysis of Atmospheric Ducts in the Yellow and Bohai Seas of China and Study of Their Electromagnetic Wave Propagation Characteristics

open access: yesAtmosphere
Atmospheric ducts play a critical role in the propagation of electromagnetic waves by minimizing signal loss and extending transmission distances, which is essential for radar, communication, and navigation systems.
Xiao Yang   +5 more
doaj   +1 more source

Surface of the rooster spermatozoon changes in passing through the Wolffian duct

open access: yes, 1985
9 p.-14 fig.Fluid secreted by the rooster Wolffian duct contains several proteins separable on polyacrylamide gel electrophoresis (PAGE) and isoelectricfocusing (IEF) gels.
Bedford, J. M., Esponda, Pedro
core   +1 more source

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